1467024-13-0Relevant articles and documents
Stereoselective palladium-catalyzed alkenylation and alkynylation of thioglycosides
Brachet, Etienne,Brion, Jean-Daniel,Alami, Mouad,Messaoudi, Samir
supporting information, p. 2627 - 2636 (2013/10/21)
An efficient and unprecedented palladium-catalyzed S-glycosylation reaction of a range of alkenyl and alkynyl halides by using thiosugars as nucleophile partners has been established. With palladium diacetate in combination with Xantphos as the catalytic system, a variety of β-alkenylthioglycosides as well as β-alkynylthioglycosides can be prepared in good to excellent yields. The efficiency of this general protocol was well-demonstrated by the formal synthesis of a leaf-closure β-glucosidase inhibitor. Copyright