146937-21-5

Basic information

• Product Name: (E)-2-<(3-phenylprop-2-enyl)thio>pyrimidine
• Synonyms: (E)-2-<(3-phenylprop-2-enyl)thio>pyrimidine
• CAS NO: 146937-21-5
• Molecular Weight: 228.318
• Mol File: 146937-21-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (E)-2-<(3-phenylprop-2-enyl)thio>pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-<(3-phenylprop-2-enyl)thio>pyrimidine(146937-21-5)
• EPA Substance Registry System: (E)-2-<(3-phenylprop-2-enyl)thio>pyrimidine(146937-21-5)

Safety Data

• Hazardous Substances Data: 146937-21-5(Hazardous Substances Data)

Upstream product

• 106625-69-8 ethyl (E)-3-phenyl-2-propenyl carbonate 
• 131242-36-9 2-sulfanylpyrimidine 
• 87802-71-9 (E)-methyl cinnamyl carbonate 

Downstream Products

• 68826-48-2 (E)-(3-cyclohexylideneprop-1-en-1-yl)benzene 

Relevant articles and documents

Palladium(0)-catalyzed alkylation of thiols

Palladium(0)-catalyzed alkylation of various allylic carbonates by aromatic thiols allowed the easy preparation of various allylic aryl sulphides in quite good yields. The reaction was regioselective with substitution at the less hindered side of the π-allyl system whatever the temperature of the reaction, and was diastereoselective with net retention of configuration.

Palladium-catalyzed allylation of pyrimidine-2,4-diones (uracils) and of 6-membered heterocyclic ambident sulfur nucleophiles

Pd(O)-Catalyzed allylation of six-membered ambident heterocycles bearing NH-CO, NH-CS and CH2-CO moieties obey the regioselectivity rules: C>O; N>O; S>N; NH-CO>NH-CS. Uracil and 5-methyluracil (thymine) do not show regioselectivity (N-1 = N-3) whereas 6-methyluracil is regioselectively allylated at N-3 (N-3>N-1).