131242-36-9Relevant articles and documents
High-purity 2-pyrimidinethiol preparation method and 2-pyrimidinethiol prepared by same
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Paragraph 0045-0051, (2017/12/30)
The invention provides a high-purity 2-pyrimidinethiol preparation method which includes the steps: (1) adding and dissolving reactant 2-chloro-pyrimidine and sulfides into solvents according to the molar ratio of 1:1, adding compound catalysts, controlling reaction temperature to react mixture, and tracking reaction by thin-layer chromatography until the 2-chloro-pyrimidine completely reacts; (2) cooling mixture to reach indoor temperature after reaction, separating out yellow tabular crystals and then performing suction filtration; (3) washing the yellow tabular crystals by water, performing recrystallization on the yellow tabular crystals by the aid of mixed solvents, and filtering and drying mixture to obtain high-purity 2-pyrimidinethiol. Reaction solvents and compound catalysts in the preparation process of the 2-pyrimidinethiol can be repeatedly used, production cost can be reduced, environmental pollution is reduced, continuous production time is saved, and manpower and material resources are saved. The high-purity 2-pyrimidinethiol prepared by the preparation method is low in production cost, good in purity, high in yield, less in environmental pollution and safer to produce, and the yield of the 2-pyrimidinethiol can reach 92.8%.
Modified Borohydride Agents, 1-Benzyl-4-aza-1-azoniabicyclooctane Tetrahydroborate (BAAOTB) versus Tetrabutylammonium Tetrahydroborate (TBATB). Efficient, Selective, and Versatile Reducing Agents
Firouzabadi, Habib,Afsharifar, Gholam Reza
, p. 2595 - 2602 (2007/10/03)
1-Benzyl-4-aza-1-azoniabicyclooctane tetrahydroborate (BAAOTB) and tetrabutylammonium tetrahydroborate (TBATB) are used for the selective reductions of aldehydes, ketones, α,β-unsaturated carbonyl compounds, acid chlorides, azides, epoxides, and disulfides in t-BuOH and hexane/chloroform.ABBOAB with its rigid and bulky structure reacts more selectively than its analogue TBATB.
Cephalosporin derivatives and bactericides containing the same
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, (2008/06/13)
Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: STR1 wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); STR2 or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): STR3 or an unsubstituted or substituted pyridinium group of a formula (I-3); STR4 or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):
