- High-purity 2-pyrimidinethiol preparation method and 2-pyrimidinethiol prepared by same
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The invention provides a high-purity 2-pyrimidinethiol preparation method which includes the steps: (1) adding and dissolving reactant 2-chloro-pyrimidine and sulfides into solvents according to the molar ratio of 1:1, adding compound catalysts, controlling reaction temperature to react mixture, and tracking reaction by thin-layer chromatography until the 2-chloro-pyrimidine completely reacts; (2) cooling mixture to reach indoor temperature after reaction, separating out yellow tabular crystals and then performing suction filtration; (3) washing the yellow tabular crystals by water, performing recrystallization on the yellow tabular crystals by the aid of mixed solvents, and filtering and drying mixture to obtain high-purity 2-pyrimidinethiol. Reaction solvents and compound catalysts in the preparation process of the 2-pyrimidinethiol can be repeatedly used, production cost can be reduced, environmental pollution is reduced, continuous production time is saved, and manpower and material resources are saved. The high-purity 2-pyrimidinethiol prepared by the preparation method is low in production cost, good in purity, high in yield, less in environmental pollution and safer to produce, and the yield of the 2-pyrimidinethiol can reach 92.8%.
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Paragraph 0045-0051
(2017/12/30)
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- NOVEL AROMATIC COMPOUND AND POLYARYLENE COPOLYMER HAVING NITROGEN-CONTAINING HETEROCYCLE INCLUDING SULFONIC ACID GROUP IN SIDE CHAIN
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Provided is a solid polymer electrolyte having increased heat resistance and high proton conductivity and a proton conductive membrane composed of the electrolyte. Also provided is a copolymer having a sulfonic acid group. The copolymer includes a repeating unit represented by Formula (1): (in the formula, Y denotes at least one kind of structure selected from the group consisting of —CO—, —SO2—, —SO—, —CONH—, —COO—, —(CF2)l— (l is an integer of 1 to 10), and —C(CF3)2—; W denotes at least one kind of structure selected from the group consisting of a direct bond, —CO—, —SO2—, —SO—, —CONH—, —COO—, —(CF2)l— (l is an integer of 1 to 10), —C(CF3)2—, —O—, and —S—; Z denotes a direct bond or at least one kind of structure selected from the group consisting of —(CH2)l—(l is an integer of 1 to 10), —C(CH3)2—, —O—, —S—, —CO—, and —SO2—; R30 denotes a nitrogen-containing aromatic ring having a substituent represented by —SO3H, —O(CH2)hSO3H, or —O(CF2)hSO3H (h is an integer of 1 to 12); p is an integer of 0 to 10; q is an integer of 0 to 10; r is an integer of 1 to 5; and k is an integer of 0 to 4).
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- Modified Borohydride Agents, 1-Benzyl-4-aza-1-azoniabicyclooctane Tetrahydroborate (BAAOTB) versus Tetrabutylammonium Tetrahydroborate (TBATB). Efficient, Selective, and Versatile Reducing Agents
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1-Benzyl-4-aza-1-azoniabicyclooctane tetrahydroborate (BAAOTB) and tetrabutylammonium tetrahydroborate (TBATB) are used for the selective reductions of aldehydes, ketones, α,β-unsaturated carbonyl compounds, acid chlorides, azides, epoxides, and disulfides in t-BuOH and hexane/chloroform.ABBOAB with its rigid and bulky structure reacts more selectively than its analogue TBATB.
- Firouzabadi, Habib,Afsharifar, Gholam Reza
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p. 2595 - 2602
(2007/10/03)
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- Cephalosporin derivatives and bactericides containing the same
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Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: STR1 wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); STR2 or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): STR3 or an unsubstituted or substituted pyridinium group of a formula (I-3); STR4 or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):
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- CONDITIONAL EQUILIBRIUM CONSTANT OF THE REACTION OF 2-MERCAPTOPYRIMIDINE WITH IODINE IN ACIDIC SOLUTION
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The reaction of 2-mercaptopyrimidine with iodine in HClO4 solution has been investigated.Conditional equilibrium constant was calculated from the known initial concentrations of 0, 0 and from the equilibrium concentration of determined by spectrophotometry.The conditional equilibrium constant in 1 M HClO4 is 307+/-24, and in 2 M HClO4 is 20+/-1.
- Kurzawa, Jan,Janowicz, Krystyna
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p. 147 - 156
(2007/10/02)
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- A DIRECT SYNTHESIS OF HETEROCYCLIC THIOLS
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Heterocyclic thiols (thiones) are conveniently synthesized in good yields by the reaction of heterocyclic halides with sodium thiosulfate.The reaction requires the presence of acid, either added or liberated during the reaction, to hydrolyze the intermediate thiosulfate to thiol.
- Foye, William O.,Abood, Norman,Kauffman, Joel M.,Kim, Young-Ho,Patel, Bhupendra R.
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p. 205 - 208
(2007/10/02)
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- Use of 2-pyrimidine thiol carbonates as acylating agents for amino or imino containing compounds
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Thiolcarbonates represented by the formula, SPC1 Wherein R1 and R2 are individually a hydrogen atom or a methyl group, and R3 is a straight chain or branched chain saturated or unsaturated alkyl group having 1 to 5 carbon atoms or is a benzyl or benzhydryl group which may be nuclear substituted, are quite useful for protecting the amino or imino groups of amines, hydrazines, amino acids and peptides with groups of the formula EQU1 The thiolcarbonates can be easily produced by reacting an alkali metal salt of 2-mercaptopyrimidine with phosgene, and reacting the resulting thiolchloroformate with an alcohol (R3 OH), or by reacting a 2-mercaptopyrimidine with a halocarbonic acid ester.
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- Process for acylation of amino, imino and hydroxyl groups using pyrimidine derivatives
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Pyrimidine derivatives represented by the formula, SPC1 Wherein R1 and R2 are individually a hydrogen atom or a methyl group, and R3 is a group formed by removing the carboxyl group from a carboxylic acid, are quite useful in acylating compounds having amino and/or imino and/or hydroxyl groups. The pyrimidine derivatives can easily be prepared by reacting a 2-mercapto-4- and/or 6-methyl-substituted or unsubstituted pyrimidine with a carboxylic acid or a reactive derivative thereof in an inert solvent.
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- 7-(3-Substituted ureido) cephalosporins
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Cephalosporin compounds with 3-substituted ureido or -thioureido group at position 7 and hydrogen or heterocyclicthiomethyl groups at position 3 are prepared. These compounds are antibacterial agents.
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