14812-59-0 Usage
Description
2-Chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane (TMDP) is an organic compound with the molecular formula C5H11ClO2P. It is a colorless liquid that is soluble in organic solvents and is widely used in various chemical reactions and applications due to its unique properties.
Uses
Used in Chemical Synthesis:
2-CHLORO-4,4,5,5-TETRAMETHYL-1,3,2-DIOXAPHOSPHOLANE is used as a reagent for the phosphitylation of alcohols and heteroatomic nucleophiles, resulting in the formation of useful glycosyl donors and ligands. This application is particularly important in the synthesis of complex organic molecules and the development of new pharmaceutical compounds.
Used in Analytical Chemistry:
2-CHLORO-4,4,5,5-TETRAMETHYL-1,3,2-DIOXAPHOSPHOLANE is used as a phosphitylation reagent to derivatize lignin samples for 31P NMR analysis. This application is crucial in the study of lignin structure and its role in the chemical properties of wood and other plant materials.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-CHLORO-4,4,5,5-TETRAMETHYL-1,3,2-DIOXAPHOSPHOLANE is used as a key intermediate in the synthesis of various drugs and drug candidates. Its ability to form stable phosphitylating agents makes it a valuable tool in the development of new therapeutic agents.
Used in Material Science:
In the field of material science, 2-CHLORO-4,4,5,5-TETRAMETHYL-1,3,2-DIOXAPHOSPHOLANE is used in the development of novel materials with unique properties. Its ability to form stable phosphorus-containing compounds makes it a valuable component in the creation of new materials with potential applications in various industries, such as electronics, energy storage, and advanced coatings.
Check Digit Verification of cas no
The CAS Registry Mumber 14812-59-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,8,1 and 2 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 14812-59:
(7*1)+(6*4)+(5*8)+(4*1)+(3*2)+(2*5)+(1*9)=100
100 % 10 = 0
So 14812-59-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H12ClO2P/c1-5(2)6(3,4)9-10(7)8-5/h1-4H3
14812-59-0Relevant articles and documents
Chemical characterization and physical properties of solvents derived from epoxidized methyl soyate
Riley, Sean J.,Verkade, John G.,Angelici, Robert J.
, p. 589 - 601 (2015)
Reactions of epoxidized methyl soyate (EMS) with alcohols, carbon dioxide, and acetone yielded liquids with solvent properties that make them more suitable than methyl soyate for dissolving polar substances. The reactions of EMS in the presence of Amberlyst-15 with alcohols, including methanol, ethanol, n-butanol, and 2-methoxyethanol, produced a series of solvents containing ether (-OR) and alcohol (-OH) groups. Reactions of EMS with carbon dioxide and acetone gave products with carbonate and ketonide functional groups, respectively. The complex mixture of compounds present in the product, EMS(MeOH), resulting from the reaction of EMS with MeOH, was characterized by MS and NMR investigations. In addition to products resulting from MeOH addition across the epoxide ring, were major amounts of cyclic tetrahydrofuran derivatives that were derived from reactions of methyl linoleate (18:2) with MeOH. All of the solvents were characterized by high boiling points and low vapor pressures. Their viscosities were higher than that of methyl soyate. Especially notable were their very high Kauributanol values, which ranged from 280 to 852, all of which are much higher than that (57) of methyl soyate. Such high KB values indicate that these solvents have very favorable solubilizing properties, which is illustrated by the ability of EMS(MeOH) to readily dissolve both polar (e.g., MeOH) and non-polar (e.g., hexane) compounds.
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Zwierzak,A.
, p. 2501 - 2512 (1967)
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Synthesis and antihypertensive activities of 1,4-dihydropyridine-5-phosphonate derivatives. II
Morita,Kunimoto,Tsuda,Tada,Kise,Kimura
, p. 4144 - 4154 (2007/10/02)
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