148259-82-9

Basic information

• Product Name: (S)-(2,4-dichlorophenyl)(phenyl)methanol
• Synonyms: (S)-(2,4-dichlorophenyl)(phenyl)methanol
• CAS NO: 148259-82-9
• Molecular Weight: 253.128
• Mol File: 148259-82-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (S)-(2,4-dichlorophenyl)(phenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(2,4-dichlorophenyl)(phenyl)methanol(148259-82-9)
• EPA Substance Registry System: (S)-(2,4-dichlorophenyl)(phenyl)methanol(148259-82-9)

Safety Data

• Hazardous Substances Data: 148259-82-9(Hazardous Substances Data)

Upstream product

• 19811-05-3 2,4-dichlorobenzophenone 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 98-80-6 phenylboronic acid 
• 3262-89-3 triphenylboroxine 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral NCP Pincer Iridium Complexes

The use of a chiral (NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent. This reaction was applicable to various ortho-substituted diaryl keontes, affording benzhydrols in good yields and enantioselectivities. This protocol could be carried out in a gram scale under mild reaction conditions. The utility of the catalytic system was highlighted by the synthesis of the key precursor of (S)-neobenodine.

Lutidine-Based Chiral Pincer Manganese Catalysts for Enantioselective Hydrogenation of Ketones

A series of MnI complexes containing lutidine-based chiral pincer ligands with modular and tunable structures has been developed. The complex shows unprecedentedly high activities (up to 9800 TON; TON=turnover number), broad substrate scope (81 examples), good functional-group tolerance, and excellent enantioselectivities (85–98 % ee) in the hydrogenation of various ketones. These aspects are rare in earth-abundant metal catalyzed hydrogenations. The utility of the protocol have been demonstrated in the asymmetric synthesis of a variety of key intermediates for chiral drugs. Preliminary mechanistic investigations indicate that an outer-sphere mode of substrate–catalyst interactions probably dominates the catalysis.

Asymmetric Hydrogenation of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos/PICA Derivative–Ruthenium(II) Complexes

The DIPSkewphos/PICA derivative-Ru(II) complexes catalyzed asymmetric hydrogenation of significantly sterically hindered 2’,3’,4’,5’,6’-pentamethylacetophenone, which was not reduced with NaBH4 at 25 °C, with a substrate-to-catalyst molar ratio