19811-05-3

Basic information

• Product Name: 2,4-DICHLOROBENZOPHENONE
• Synonyms: DICHLOROBENZOPHENONE(2,4-);Methanone,(2,4-dichlorophenyl)phenyl-;Benzoyl-2,4-dichlorobenzene
• CAS NO: 19811-05-3
• Molecular Formula: C₁₃H₈Cl₂O
• Molecular Weight: 251.11
• EINECS: 243-338-6
• Product Categories: Aromatic Benzophenones & Derivatives (substituted)
• Mol File: 19811-05-3.mol
• Article Data: 20

Chemical Properties

• Melting Point: 47°C
• Boiling Point: 366.1 °C at 760 mmHg
• Flash Point: 154.8 °C
• Appearance: /
• Density: 1.311
• Vapor Pressure: 1.5E-05mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: very faint turbidity in Methanol
• CAS DataBase Reference: 2,4-DICHLOROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLOROBENZOPHENONE(19811-05-3)
• EPA Substance Registry System: 2,4-DICHLOROBENZOPHENONE(19811-05-3)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 19811-05-3(Hazardous Substances Data)

Usage

Uses

2,4-Dichlorobenzophenone is a useful synthetic compound.

InChI:InChI=1/C13H8Cl2O/c14-10-6-7-11(12(15)8-10)13(16)9-4-2-1-3-5-9/h1-8H

Upstream product

• 98-88-4 benzoyl chloride 
• 541-73-1 1,3-Dichlorobenzene 
• 89-75-8 2,4-dichlorobenzoyl chloride 
• 71-43-2 benzene 
• 201230-82-2 carbon monoxide 
• 68716-47-2 2,4-dichlorophenylboronic acid 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 88691-50-3 (2,4-dichlorophenyl)methanesulfonyl chloride 
• 29898-32-6 2,4-dichloro-1-iodo-benzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 1657-47-2 (E)-2,4-dichloro-1-styrylbenzene 
• 36967-85-8 benzoyl triflate 

Downstream Products

• 56431-07-3 2,4-dichloro-α-ethyl-benzhydrol 
• 65-85-0 benzoic acid 
• 541-73-1 1,3-Dichlorobenzene 
• 61023-63-0 α-(2,4-dichlorophenyl) phenyl acetaldehyde 
• 148259-82-9 (S)-(2,4-dichlorophenyl)(phenyl)methanol 
• 61023-67-4 β-(2,4-dichlorophenyl) phenethanol 
• 139029-71-3 2,4-dichloro-benzhydryl chloride 
• 1313616-31-7 2,4-dichlorobenzhydryl-1H-1,2,4-triazole 
• 1313616-26-0 2,4-dichlorobenzhydryl-1H-imidazole 
• 49823-03-2 (2,4-dichloro-phenyl)-(1-methoxymethyl-1H-imidazol-2-yl)-phenyl-methanol 
• 29334-23-4 2,4-dichloro-α-phenylbenzenemethanol 
• 118173-60-7 (2,4-dichlorophenyl)phenyl(2-methylthiazol-5-yl)carbinol 
• 118173-59-4 (2,4-Dichloro-phenyl)-phenyl-thiazol-5-yl-methanol 
• 127568-39-2 N-[(2,4-Dichloro-phenyl)-phenyl-methyl]-formamide 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral NCP Pincer Iridium Complexes

The use of a chiral (NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent. This reaction was applicable to various ortho-substituted diaryl keontes, affording benzhydrols in good yields and enantioselectivities. This protocol could be carried out in a gram scale under mild reaction conditions. The utility of the catalytic system was highlighted by the synthesis of the key precursor of (S)-neobenodine.

Decarboxylation with Carbon Monoxide: The Direct Conversion of Carboxylic Acids into Potent Acid Triflate Electrophiles

We report a new strategy for the conversion of carboxylic acids into potent acid triflate electrophiles. The reaction involves oxidative carbonylation of carboxylic acids with I2 in the presence of AgOTf, and is postulated to proceed via acyl hypoiodites that react with CO to form acid triflates. Coupling this chemistry with subsequent trapping with arenes offers a mild, room temperature approach to generate ketones directly from broadly available carboxylic acids without the use of corrosive and reactive Lewis or Bronsted acid additives, and instead from compounds that are readily available, stable, and functional group compatible.

Tetraethylammonium iodide catalyzed synthesis of diaryl ketones via the merger of cleavage of C-C double bonds and recombination of aromatic groups

An efficient method for synthesizing diaryl ketones via merging of oxidative cleavage of C-C double bonds and recombination of aromatic groups is developed with Et4NI (2.5 mol%) as the catalyst and NaIO4 as the oxidant. The control experiments provide valuable mechanistic insights into the formation of diaryl ketones, and suggest that NaIO4 serves as an epoxidation and nucleophilic deformylation reagent.