149427-84-9

Basic information

• Product Name: 5-(2-HYDROXY-ETHYL)-PYRROLIDIN-2-ONE
• Synonyms: 5-(2-HYDROXY-ETHYL)-PYRROLIDIN-2-ONE;5-(2-hydroxyethyl)-2-Pyrrolidinone
• CAS NO: 149427-84-9
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.15704
• Mol File: 149427-84-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 342.383 °C at 760 mmHg
• Flash Point: 160.868 °C
• Appearance: /
• Density: 1.11 g/cm³
• CAS DataBase Reference: 5-(2-HYDROXY-ETHYL)-PYRROLIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-HYDROXY-ETHYL)-PYRROLIDIN-2-ONE(149427-84-9)
• EPA Substance Registry System: 5-(2-HYDROXY-ETHYL)-PYRROLIDIN-2-ONE(149427-84-9)

Safety Data

• Hazardous Substances Data: 149427-84-9(Hazardous Substances Data)

Upstream product

• 67036-44-6 methyl (S)-2-(5-oxopyrrolidin-2-yl)acetate 
• 17342-08-4 (S)-Pyroglutaminol 
• 51693-17-5 (S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester 
• 72479-06-2 2-[(2S)-5-oxopyrrolidin-2-yl]acetonitrile 
• 124201-75-8 (S)-(5-oxo-pyrrolidin-2-yl)-acetic acid ethyl ester 
• 4931-66-2 methyl (S)-pyroglutamate 
• 572889-82-8 (1R,5R,6R)-2-tert-butyl 6-methyl 2-azabicyclo[3.1.0]hex-3-ene-2,6-dicarboxylate 
• 321133-39-5 (-)-2-azabicyclo[3.1.0]hex-3-ene-2,6-dicarboxylic acid 2-tert-butyl ester 6-methyl ester 
• 881405-71-6 (1R,5R,6R)-4-bromo-3-oxo-2-azabicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-tert-butyl ester 6-methyl ester 
• 881405-69-2 (2S)-2-methoxycarbonylmethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester 
• 881405-70-5 (2R)-2-methoxycarbonylmethyl-5-oxo-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 881405-68-1 (2S)-2-methoxycarbonylmethyl-5-oxo-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 854027-99-9 (S)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pyrrolidin-2-one 
• 936114-75-9 methyl (3aS,4S,9bS)-4-(3-azidopropyl)-2,3,3a,4,5,9b-hexahydro-1-(phenylmethyl)-1H-pyrrolo-[3,2-c]quinoline-8-carboxylate 
• 936114-98-6 1-benzyl-4-(3-methanesulfonyloxy-propyl)-5-trifluoroacetyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-8-carboxylic acid methyl ester 
• 936114-95-3 methyl (3aS,4S,9bS)-2,3,3a,4,5,9b-hexahydro-5-(3-oxobutanoyl)-1-(phenylmethyl)-5-(trifluoroacetyl)-1H-pyrrolo[3,2-c]quinoline-8-carboxylate 
• 936114-71-5 methyl (3aS,4S,9bS)-2,3,3a,4,5,9b-hexahydro-5-(3-oxobutanoyl)-1-(phenylmethyl)-1H-pyrrolo-[3,2-c]quinoline-8-carboxylate 
• 936114-66-8 (3aS,4S,9bS)-8-iodo-2,3,3a,4,5,9b-hexahydro-5-(3-oxobutanoyl)-1-(phenylmethyl)-1H-pyrrolo-[3,2-c]quinoline-4-propyl acetate 
• 936114-61-3 (3aS,4S,9bS)-8-iodo-2,3,3a,4,5,9b-hexahydro-1-(phenylmethyl)-1H-pyrrolo[3,2-c]quinoline-4-propanol 
• 143771-09-9 (R)-2-(4-Oxo-heptyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 143771-08-8 (S)-2-((E)-4-Oxo-hept-2-enyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 74046-07-4 (+)-Vigabatrin 
• 936114-10-2 methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxyethyl]}-2-oxo-1-pyrrolidinyl]benzoate 
• 936114-41-9 methyl 5-amino-2-[(5S)-5-{[(tert-butyl)dimethylsilyiloxyethyl]}-2-oxo-1-pyrrolidinyl]benzoate 
• 936114-46-4 methyl 5-iodo-2-[(5S)-5-(hydroxyethyl)-2-oxo-1-pyrrolidinyl]benzoate 
• 936114-30-6 methyl 5-iodo-2-[(5S)-5-(ethenyl)-2-oxo-1-pyrrolidinyl]benzoate 

Relevant articles and documents

Synthesis of functionalized pyrrolidin-2-ones and (S)-vigabatrin from pyrrole

Starting from pyrrole, the novel 3,4-didehydropyrohomoglutamate 8 or (ent)-8 can be efficiently synthesized in up to 91% ee, which can be utilized as a versatile building block toward functionalized pyrrolidin-2-ones. Moreover, (ent)-8 can be readily converted to (S)-Vigabatrin, being an irreversible inhibitor for GABA-T, which is used as adjunctive therapy in patients that suffer from epilepsy.

NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE

Pharmaceutical compositions of the invention comprise functionalized lactam derivatives of formula (I) having a disease-modifying action in the treatment of diseases associated with dysregulation of 5- hydroxytryptamine receptor 7 activity. A is selected

An asymmetric total synthesis of martinellic acid

We describe an asymmetric total synthesis of the pyrrolo[3,2-c]quinoline natural product martinellic acid starting from pyrroglutamic acid. A convergent strategy involving a Pd-catalyzed aryl amination reaction of a chiral, non-racemic pyrrolidine derivative incorporates the C2-chiral center which controls the remaining two stereocenters. Elaboration of this adduct through a Grieco-elimination sets the stage for a diastereoselective intramolecular [3+2] azomethine ylide-alkene cycloaddition and the construction of the remaining two chiral centers. Elaboration of the cycloadduct and incorporation the prenyl guanidine units delivered martinellic acid after removal of the protecting groups.