14990-09-1Relevant articles and documents
New N-pyrazole, P-phosphine hybrid ligands and their reactivity towards Pd(II): X-ray crystal structures of complexes with [PdCl2(N,P)] core
Guerrero, Miguel,Mu?oz, Sergio,Ros, Josep,Calvet, Teresa,Font-Bardía, Mercè,Pons, Josefina
, p. 257 - 264 (2015)
Two new N-pyrazole, P-phosphine hybrids ligands: 1-[2-(diphenylphosphanyl)methyl]-3,5-dimethylpyrazole (LP1) and 1-[2-(diphenylphosphanyl)propyl]-3,5-dimethylpyrazole (LP3) are presented. The reaction of these two ligands and two other ligands reported in
Diastereoselective Synthesis of Highly Substituted, Amino- and Pyrrolidino-Tetrahydrofurans as Lead-Like Molecular Scaffolds
Wales, Steven M.,Merisor, Elena G.,Adcock, Holly V.,Pearce, Christopher A.,Strutt, Ian R.,Lewis, William,Hamza, Daniel,Moody, Christopher J.
, p. 8233 - 8239 (2018)
A series of highly substituted tetrahydrofurans (THFs), decorated with modifiable 2-aryl, 3-carboxy and 4-amino substituents, has been prepared for biological evaluation within the European Lead Factory. Diastereoselective reductive amination of pre-functionalised 4-oxofurans, readily prepared from cinnamate esters via oxa-Michael/Dieckmann annulation, provided the requisite THF cores on gram scale with three contiguous stereocentres, including full substitution at C-3. In a second series, a pyrrolidine ring was fused to the same oxofuran scaffold via an intramolecular reductive amination, inverting the configuration at C-4 relative to the other ring substituents. The resulting compounds, which displayed desirable physical properties as lead-like scaffolds, were derivatised into a small library of 24 compounds, demonstrating their ability to serve as starting points for drug discovery. Ultimately, this chemistry enabled the preparation of 1948 THF-containing compounds for inclusion in the Joint European Compound Library.
Palladium supported on polyether-functionalized mesoporous silica. Synthesis and application as catalyst for Heck coupling reaction
Grandsirea, Anne Flore,Labordeb, Coralie,Lamaty, Frederic,Mehdia, Ahmad
, p. 179 - 183 (2010)
A new catalytic system based on Pd supported on polyether-functionalized mesoporous silica was prepared. This material was obtained by co-hydrolysis and polycondensation of tetraethylorthosilicate and a bis-silylated triblock copolymer P123 (Mw = 5800) followed by the decomposition of Pd(OAc)2 salt. We have shown that this material can be applied as powerful heterogeneous catalyst for the Heck coupling reaction. Copyright
Solvent-controlled selective synthesis of a trans-configured benzimidazoline-2-ylidene palladium(II) complex and investigations of its Heck-type catalytic activity
Huynh, Han Vinh,Ho, Joanne Hui Hui,Neo, Tiong Cheng,Koh, Lip Lin
, p. 3854 - 3860 (2005)
Reaction of N,N′-dimethylbenzimidazolyl iodide (A) with Pd(OAc) 2 in DMSO gives selectively trans-bis(N,N′- dimethylbenzimidazoline-2-ylidene) palladium(II) diiodide (trans-2) in 77% yield. The selective formation of the trans-coordination isom
Microwave-assisted copper-catalyzed heck reaction in PEG solvent
Declerck, Valérie,Martinez, Jean,Lamaty, Frédéric
, p. 3029 - 3032 (2006)
A catalytic system made of a copper salt, potassium carbonate and PEG 3400 was developed to perform a Heck arylation under microwave activation. Copper iodide gave the best results in a short reaction time (30 min) and various substituted tert-butyl cinna
Effect of N1-substituted pyrazolic hybrid ligands on palladium catalysts for the Heck reaction
Guerrero, Miguel,Pons, Josefina,Ros, Josep
, p. 1957 - 1960 (2010)
In this paper we have explored the influence of several linkers present on the [PdCl2(L)] complexes, where L is 3,5-dimethylpyrazolic hybrid ligand N1-substituted by polyether chains and/or phenyl groups. These complexes have been used as pre-c
The effect of high pressure on the heck reaction - A contribution to a deeper understanding of the mechanism
Buback, Michael,Perkovic, Thomas,Redlich, Stefan,De Meijere, Armin
, p. 2375 - 2382 (2003)
The influence of high pressure on the Heck reactions of iodobenzene with methyl, ethyl and tert-butyl acrylate, and of both 4-nitrophenyl iodide and 4-nitrophenyl triflate with methyl acrylate, has been studied for the first time by quantitative on-line F
Heteroleptic copper(I) complexes as energy transfer photocatalysts for the intermolecular [2 + 2] photodimerization of chalcones, cinnamates and cinnamamides
Wu, Qing-An,Ren, Chen-Chao,Chen, Feng,Wang, Tian-Qi,Zhang, Yu,Liu, Xue-Fen,Chen, Jian-Bin,Luo, Shu-Ping
supporting information, (2021/05/10)
The [2 + 2] photodimerization of chalcones, cinnamates and cinnamamides can be effectively catalyzed by heteroleptic copper(I) complexes. The reactions were carried out under mild reaction conditions and the products were obtained in 20–72% yield under visible light irradiation. The copper-based photocatalyst comprised of the rigid phenanthroline ligand with substituents at the 2,9-positions and the 4,7-positions showed high activity in the photodimerization via an energy transfer pathway.
Gelatin-pyrolyzed mesoporous N-doped carbon supported Pd as high-performance catalysts for aqueous Heck reactions
Yang, Shuai,Chen, Yuli,Huang, Shuaijian,Deng, Lu,Wu, Yuanyuan,Zheng, Xiu,Omonov, Shakhzodjon,Zeng, Minfeng
, (2021/05/19)
Nitrogen-doped mesoporous carbon-supported Pd (Pd@N-C) catalysts were prepared by pyrolyzing gelatin/templates/PdCl2 hydrogels under N2 atmosphere at 800°C. Using poly (ethylene glycol) block poly (propylene glycol) block poly (ethyl
