1501971-58-9

Basic information

• Product Name: (4R)-4-benzyl-3-((2R,3S,4R)-3-hydroxy-2,4-dimethylhexanoyl)oxazolidin-2-one
• Synonyms: (4R)-4-benzyl-3-((2R,3S,4R)-3-hydroxy-2,4-dimethylhexanoyl)oxazolidin-2-one
• CAS NO: 1501971-58-9
• Molecular Weight: 319.401
• Mol File: 1501971-58-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4R)-4-benzyl-3-((2R,3S,4R)-3-hydroxy-2,4-dimethylhexanoyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-4-benzyl-3-((2R,3S,4R)-3-hydroxy-2,4-dimethylhexanoyl)oxazolidin-2-one(1501971-58-9)
• EPA Substance Registry System: (4R)-4-benzyl-3-((2R,3S,4R)-3-hydroxy-2,4-dimethylhexanoyl)oxazolidin-2-one(1501971-58-9)

Safety Data

• Hazardous Substances Data: 1501971-58-9(Hazardous Substances Data)

Upstream product

• 101711-78-8 (3R)-3-propionyl-4-benzyloxazolidin-2-one 
• 33204-48-7 (R)-2-methylbutanal 
• 1239664-46-0 (R)-4-benzyl-3-[(S)-2-(tert-butyldimethylsilyloxymethyl)butanoyl]oxazolidin-2-one 
• 907593-86-6 (R)-4-benzyl-3-[(S)-2-(hydroxymethyl)butanoyl]oxazolidin-2-one 
• 645386-89-6 (R)-4-benzyl-3-((S)-2-(benzyloxymethyl)butanoyl)-1,3-oxazolidin-2-one 
• 616-16-0 (R)-2-Methyl-1-butanol 
• 474828-48-3 (R)-4-benzyl-3-((R)-2-methylbutanoyl) oxazolidin-2-one 
• 111292-87-6 (R)-3-(1-butyryl)-4-benzyloxazolidine-2-one 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 

Downstream Products

• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 101711-78-8 (3R)-3-propionyl-4-benzyloxazolidin-2-one 
• 1501971-59-0 (2R,3S,4R)-1-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2,4-dimethyl-1-oxohexan-3-yl-4-methylbenzenesulfonate 

Relevant articles and documents

Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities

A collective synthesis of 4-hydroxy-2-pyridone alkaloids - specifically, pretenellin B, prebassianin B, farinosone A, militarione D, pyridovericin, and torrubiellone C - has been achieved. Key steps include using a strategic convergent method to synthesize the densely substituted pyridone key intermediate by Suzuki-Miyaura cross-coupling reaction, a divergent synthesis approach of target molecules by aldol condensation of pyridone intermediate with homologous aldehydes, and an iterative synthesis of homologous aldehydes with all-trans-polyene backbones. Interestingly, among the six tumor cell lines investigated, torrubiellone C was found to induce potent and apoptotic inhibitory activities on Jurkat T cells with IC50 values of 7.05 μM. Hence, this approach could potentially contribute to the synthesis of bioactive small-molecule libraries as well as drug discovery.