151052-40-3

Basic information

• Product Name: 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde
• Synonyms: 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde
• CAS NO: 151052-40-3
• Molecular Weight: 250.26
• Mol File: 151052-40-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: >176°C (dec.)
• Boiling Point: 516.3±60.0 °C(Predicted)
• Density: 1.319±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde(151052-40-3)
• EPA Substance Registry System: 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde(151052-40-3)

Safety Data

• Hazardous Substances Data: 151052-40-3(Hazardous Substances Data)

Usage

Description

2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde is an organic compound characterized by its tetrazol and biphenyl structures. It is an impurity found in Losartan Potassium, a medication used to treat high blood pressure and heart failure.

Uses

Used in Pharmaceutical Industry:
2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde is used as an impurity in the production of Losartan Potassium (L470500), an angiotensin II antagonist. It plays a role in the development and formulation of this medication, which is crucial for managing high blood pressure and heart failure in patients.
Additionally, as an impurity in Losartan Potassium, 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde contributes to the drug's effectiveness in significantly reducing the risk of new onset atrial fibrillation and associated stroke in high-risk patients. This makes it an important component in the pharmaceutical industry for the development and production of life-saving medications.

Upstream product

• 73096-42-1 5-(2-bromophenyl)-1H-tetrazole 
• 87199-17-5 4-formylphenylboronic acid, 
• 135689-93-9 4-(2-Cyanophenyl)benzaldehyde 
• 154709-19-0 4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile 
• 676130-00-0 5-(2-chlorophenyl)-2-(tetrahydropyran-2-yl)-2H-tetrazole 
• 676130-01-1 5-(2-chlorophenyl)-1-(tetrahydropyran-2-yl)-1H-tetrazole 
• 24856-58-4 1,1-dimethoxy-1-(4-bromophenyl)methane 
• 133292-05-4 4-(diethoxymethyl)phenylmagnesium bromide 
• 34421-94-8 4-bromobenzaldehyde diethyl acetal 
• 676130-02-2 5-(2-bromophenyl)-2-(tetrahydropyran-2-yl)-2H-tetrazole 
• 160514-13-6 5-(4'-hydroxymethyl-biphenyl-2-yl)-1H-tetrazole 
• 676130-06-6 5-(4'-diethoxymethyl-biphenyl-2-yl)-2-(tetrahydro-pyran-2-yl)-2H-tetrazole 

Downstream Products

• 676129-92-3 desvaleroyl valsartan 
• 676129-91-2 3-methyl-2{[1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]-meth-(E/Z)-ylidene]-amino}-butyric acid 

Relevant articles and documents

Efficient, protection-free Suzuki-Miyaura synthesis of ortho- biphenyltetrazoles

We describe an efficient protocol for the Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles from non-protected 2-bromophenyltetrazole and arylboronic acids. The optimised conditions were achieved using [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) as catalyst and Na2CO3 as base. A panel of structurally diverse arylboronic acids was used to demonstrate the scope of the coupling procedure.

COUPLING REACTIONS USEFUL IN THE PREPARATION OF (1H-TETRAZOL-5-YL)-BIPHENYL DERIVATIVES

The present invention relates to a process for the manufacture of intermediates that may be used for the manufacture of ARBs (also called angiotension II receptor antagonists or AT1 receptor antagonists) comprising as a common structural feature a (lH-tet

2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-CARBALDEHYDE CRYSTAL AND ITS MANUFACTURING METHOD

PROBLEM TO BE SOLVED: To provide a method for industrially manufacturing 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde crystal of high purity with a high yield in a short step using an inexpensive reagent. SOLUTION: The manufacturing method of 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde crystal of high purity comprises a step for reacting 2'-cyanobiphenyl-4-carbaldehyde with an azide salt and a step for crystallizing the crude 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde crystal obtained by the above step from tetrahydrofuran.