15190-69-9

Basic information

• Product Name: (4-methoxyphenyl)(phenylamino)acetonitrile
• Synonyms: (4-Methoxy-phenyl)-phenylamino-acetonitrile
• CAS NO: 15190-69-9
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.2845
• Mol File: 15190-69-9.mol
• Article Data: 98

Chemical Properties

• Boiling Point: 413.3°C at 760 mmHg
• Flash Point: 203.8°C
• Density: 1.166g/cm³
• Vapor Pressure: 4.84E-07mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: (4-methoxyphenyl)(phenylamino)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methoxyphenyl)(phenylamino)acetonitrile(15190-69-9)
• EPA Substance Registry System: (4-methoxyphenyl)(phenylamino)acetonitrile(15190-69-9)

Safety Data

• Hazardous Substances Data: 15190-69-9(Hazardous Substances Data)

Usage

General Description

"(4-methoxyphenyl)(phenylamino)acetonitrile" is a chemical compound with the molecular formula C16H14N2O. It is a nitrile derivative with a methoxyphenyl group and a phenylamino group attached to a central acetonitrile moiety. (4-methoxyphenyl)(phenylamino)acetonitrile is commonly used in organic synthesis as a building block for the preparation of other chemical compounds. It can undergo various types of reactions, such as nucleophilic substitution and condensation reactions, to form different types of functionalized molecules. It may also have potential applications in pharmaceutical and agrochemical industries due to its unique chemical structure and reactivity. Additionally, it is important to handle this compound with proper safety precautions due to its potential hazards and toxicity.

Upstream product

• 151-50-8 potassium cyanide 
• 142-04-1 aniline hydrochloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 1613-96-3 N-(4-methoxybenzylidene)aniline 
• 557-21-1 zinc(II) cyanide 
• 62-53-3 aniline 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 773837-37-9 sodium cyanide 
• 104-93-8 p-methylanizole 
• 105-13-5 4-Methoxybenzyl alcohol 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 3526-43-0 N-(4-methoxybenzyl)aniline 
• 100-52-7 benzaldehyde 

Downstream Products

• 1256842-42-8 ethyl 3-cyano-3-phenylamino-3-(4-methoxyphenyl)propanoate 
• 154319-87-6 N-Phenyl-N-(α-cyano-α-methyl-p-methoxybenzyl)-p-fluorobenzamide 
• 154319-67-2 N-Phenyl-N-(α-cyano-p-methoxybenzyl)-p-fluorobenzamide 
• 56301-84-9 1-(4-Methoxy-phenyl)-N¹-phenyl-ethane-1,2-diamine 
• 54615-68-8 (4-methoxy-phenyl)-phenylimino-acetonitrile 

Relevant articles and documents

Application of various types of alumina and nano-γ- Alumina sulfuric acid in the synthesis of α-aminonitriles derivatives: Comparative study

An efficient and green protocol for the synthesis of α-aminonitrile derivatives by one-pot reaction of different aldehydes with amines and trimethylsilyl cyanide has been developed using natural alumina, alumina sulfuric acid (ASA), nano-γ-alumina, nano-γ

A carbon dioxide-promoted three-component Strecker reaction

A three-component Strecker reaction of aldehydes, amines and KCN has been performed for the first time in supercritical carbon dioxide. In the proposed procedure, non-toxic and non-flammable carbon dioxide acts not only as an environmentally benign reaction medium but also as a reaction promoter via in situ formation of carbonic acid which provides a gradual release of the true cyanating agent (HCN) from available KCN. The reaction conditions (pressure, temperature, and concentrations of reagents) were optimized, and various aromatic and aliphatic amines and aldehydes were transformed into valuable α-amino nitriles including prospective pharmacological substances. The equimolar amount of used cyanogen reagent, carrying out the process in a sealed autoclave in a 'green' solvent medium under mild conditions (90 bar, 35 °C) along with the high yields of products and the scalability of the developed procedure make it suitable for sustainable industrial applications. This journal is

Synthesis and characterization of Pd supported on methane diamine (propyl silane) functionalized Fe3O4 nanoparticles as a magnetic catalyst for synthesis of α-aminonitriles and 2-methoxy-2-phenylacetonitrile derivative via Strecker-t

Pd supported on methane diamine (propyl silane) functionalized Fe3O4 magnetic nanoparticles as an organic–inorganic hybrid heterogeneous catalyst was fabricated and characterized by FT-IR, XRD, SEM, TEM, TGA, VSM, EDX, and ICP-AES te

Fe3O4?SiO2 nanoparticles–functionalized Cu(II) Schiff base complex with an imidazolium moiety as an efficient and eco-friendly bifunctional magnetically recoverable catalyst for the Strecker synthesis in aqueous media at room temperature

Cu(II) Schiff base complex supported on Fe3O4?SiO2 nanoparticles was employed as a magnetic nanocatalyst (nanocomposite) with a phase transfer functionality for the one-pot preparation of α-aminonitriles (Strecker reaction). The desired α-aminonitriles were obtained from the reaction of aromatic or aliphatic aldehydes, aniline or benzyl amine, NaCN, and 1.6 mol% of the catalyst in water at room temperature and good to excellent yields were obtained for all substrates. The catalyst was characterized analytically and instrumentally including Fourier-transform infrared spectroscopy, X-ray diffraction, thermogravimetric, nuclear magnetic resonance, energy-dispersive X-ray spectroscopy, inductively coupled plasma spectroscopy, vibrating-sample magnetometry analysis, dynamic light scattering, Brunauer–Emmett–Teller surface area, field emission scanning electron microscopy, and transmission electron microscopy analyses. The reaction mechanism was investigated, in which the performance of the catalyst as a phase transition factor seems to be probable. The catalyst showed high activity, high turnover frequency (TOF)s, significant selectivity, and fast performance toward the Strecker synthesis. The nanocatalyst can be readily and quickly separated from the reaction mixture with an external magnet and can be reused for at least seven successive reaction cycles without significant reduction in efficiency.