153413-66-2

Basic information

• Product Name: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[4-nitrophenyl bis(1-methylethyl)phosphoramidite]
• CAS NO: 153413-66-2
• Molecular Formula: C43H49N4O10P
• Molecular Weight: 812.857
• Mol File: 153413-66-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[4-nitrophenyl bis(1-methylethyl)phosphoramidite](CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[4-nitrophenyl bis(1-methylethyl)phosphoramidite](153413-66-2)
• EPA Substance Registry System: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[4-nitrophenyl bis(1-methylethyl)phosphoramidite](153413-66-2)

Safety Data

• Hazardous Substances Data: 153413-66-2(Hazardous Substances Data)

Upstream product

• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 153413-65-1 O,O'-bis-(4-nitrophenyl) N,N-diisopropylphosphoramidite 
• 100-02-7 4-nitro-phenol 
• 824-78-2 4-nitrophenol sodium salt 
• 921-26-6 N,N-diisopropylphosphoramide dichloride 
• 162611-31-6 4-nitrophenyl-N,N-diisopropylchlorophosphoramidite 

Downstream Products

• 153413-68-4 C₆₉H₆₇Cl₂N₄O₁₄PS 
• 153413-67-3 C₆₈H₆₆N₅O₁₇P 
• 153413-69-5 S-(2,4-dichlorobenzyl)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(4,4'-dimethoxytrityl)thymidin-5-yl phosphoroselenothioate 
• 153454-34-3 C₆₉H₆₇Cl₂N₄O₁₄PS₂ 
• 57538-75-7 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen phosphorofluoridate 
• 171081-14-4 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) phosphorofluoridate 
• 171081-18-8 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate 
• 171081-10-0 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) phosphorofluoridite 
• 182370-37-2 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen thiophosphorofluoridate 
• 153454-33-2 O-[5'-O-(4,4-dimethoxytrityl)thymidin-3-yl]-O-[3'-O-(4,4-dimethoxytrityl)thymidin-5'-yl]N,N-diisopropylphosphoramidite 
• 162611-40-7 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl-(N,N-diisopropylamino)phosphorofluoridite 

Relevant articles and documents

Synthesis of phosphorofluoridates and phosphorofluoridothioates via the phosphoramidite approach

We present a very efficient synthetic procedure leading to the phosphorofluoridates RO-P(O)(OH)F 1 or phosphorofluoridothioates RO-P(S)(OH)F 2, which is based on the intermediary of fluorophosphoramidites (RO)P(F)N iPr2 5 [R = 9-(hyd

New efficient synthesis of thymidine cyclic 3′, 5′-phosphorofluoridate and its sulfur analogue via the phosphoroamidite route

We describe the convenient synthesis of thymidine cyclic 3′, 5′-phosphorofluoridate 6, which is superior to that previously reported. Our procedure is based on a sequence of reactions utilizing 3 as the key substrate. Similar sequence of reaction leads to

New phosphitylating reagent in the nucleotide chemistry containing two 4-nitrophenoxy leaving groups. Remarkably fast and clean phosphitylations activated by DBU leading to thio- and seleno-oligonucleotides

A new synthetic approach to modified oligonucleotides based on N,N′-diisopropyl-di-(4-nitrophenyl)phosphoroamidite 1 is described. The procedure involves displacement of either 4-nitrophenoxy or diisopropylamino ligands. The former proceeds very fast in t