153645-26-2Relevant articles and documents
A convenient synthesis of (1S)-tert-butyl-1,2-ethylenediamine
Busacca, Carl A.,Grossbach, Danja,Spinelli, Earl
, p. 1907 - 1910 (2000)
A practical four-step synthesis of (1S)-tert-butyl-1,2-ethylenediamine has been developed. The sequence proceeds in good overall yield via crystalline intermediates and provides the title compound in 99.3% ee. Copyright (C) 2000 Elsevier Science Ltd.
N-1 BRANCHED ALKYL ETHER SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS
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, (2020/06/19)
Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.
Isoselective ring-opening polymerization and asymmetric kinetic resolution polymerization of: Rac -lactide catalyzed by bifunctional iminophosphorane-thiourea/urea catalysts
Lv, Chengdong,Zhou, Li,Yuan, Ruiting,Mahmood, Qaiser,Xu, Guangqiang,Wang, Qinggang
supporting information, p. 1648 - 1655 (2020/02/04)
A series of iminophosphorane-thiourea/urea bifunctional catalysts was synthesized and utilized for the isoselective ring-opening polymerization of rac-lactide. The ROPs were promoted efficiently, affording the polylactides with controlled molecular weight, narrow molecular weight distribution and well-defined end groups without undesired side reactions. The experiment data revealed that ROPs of rac-LA are a "controlled/living" process. The highest stereoselectivity (Pm) was up to 0.80 using rac-IPU-1 under mild reaction conditions. The mechanistic study indicated that stereoselective ROPs of rac-LA were mainly controlled by a chain-end control mechanism when using rac/(R,R)-IPTU-1/IPU-1 as catalysts. Additionally, the ee values of -11% at 0 °C and -17% at -40 °C were achieved at about 50% conversion using (S)-IPU-2 as a chiral catalyst. The selectivity factor (s = kL/kD) of 1.6 indicated that a clear kinetic resolution occurred and the enantiomorphic site control mechanism was involved.