176504-88-4

Basic information

• Product Name: L-VALINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHYL-, METHYL ESTER
• Synonyms: L-VALINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHYL-, METHYL ESTER;(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoate
• CAS NO: 176504-88-4
• Molecular Formula: C₁₂H₂₃NO₄
• Molecular Weight: 245.32
• Mol File: 176504-88-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: L-VALINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHYL-, METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: L-VALINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHYL-, METHYL ESTER(176504-88-4)
• EPA Substance Registry System: L-VALINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHYL-, METHYL ESTER(176504-88-4)

Safety Data

• Hazardous Substances Data: 176504-88-4(Hazardous Substances Data)

Usage

General Description

L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-, methyl ester is a chemical compound that is a methyl ester derivative of N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valine. Valine is an essential amino acid that plays a crucial role in protein synthesis and muscle repair. The ester form of valine is commonly used in pharmaceuticals and research as a chemical building block and as a precursor for the synthesis of other compounds. It is also used as a flavoring agent in the food industry. This chemical compound has applications in various industries and is an important ingredient in the development of drugs, food products, and other commercial products.

Upstream product

• 186581-53-3 diazomethane 
• 62965-35-9 N-tert-butyloxycarbonyl-L-tert-leucine 
• 74-88-4 methyl iodide 
• 335628-21-2 (4S,5R)-3-tert-butoxycarbonyl-4-tert-butyl-5-methoxy-2-oxazolidinone 
• 24424-99-5 di-tert-butyl dicarbonate 
• 63038-26-6 (S)-2-amino-3,3-dimethyl-butyric acid methyl ester 
• 335627-81-1 (4S,5R)-4-tert-butyl-5-methoxy-2-oxazolidinone 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 176504-89-5 dimethyl <(3S)-4,4-dimethyl-3-<(tert-butoxycarbonyl)amino>-2-oxopentyl>phosphonate 
• 153645-26-2 N-Boc-L-tert-leucinol 
• 63038-26-6 (S)-2-amino-3,3-dimethyl-butyric acid methyl ester 
• 630421-45-3 methyl (2S_.4R)-1-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3.3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxylate 
• 176504-91-9 benzyl (E)-(5S)-6,6-dimethyl-5-<(tert-butoxycarbonyl)amino>-4-oxo-2-heptenoate 

Relevant articles and documents

Organocatalytic ?±-addition of isocyanides to aldehydes

?±-Hydroxyamide is an important chemical component widely observed in biologically active natural products. One of the most direct methods to access a ?±-hydroxyamide is the Passerini-type reaction. However, this catalytic process was limited. Herein, we

Nucleophilic acyl substitutions of anhydrides with protic nucleophiles catalyzed by amphoteric, oxomolybdenum species

(Chemical Equation Presented) Among six different group VIb oxometallic species examined, dioxomolybdenum dichloride and oxomolybdenum tetrachloride were the most efficient catalysts to facilitate nucleophilic acyl substitution (NAS) of anhydrides with a myriad array of alcohols, amines, and thiols in high yields and high chemoselectivity. In contrast to the well-recognized redox chemical behaviors associated with oxomolybdenum(VI) species, the catalytic NAS was unprecedented and tolerates virtually all kinds of functional groups. By using benzoic anhydride as a mediator for in situ generation of an incipient mixed anhydride-MoO2Cl2 adduct with a given functional alkanoic acid, one can achieve oleate, dipeptide, diphenylmethyl, N-Fmoc-α-amino, pyruvic, and tert-butylthio ester, N-tert-butylamide, and trityl methacrylate syntheses with appropriate protic nucleophiles. The amphoteric character of the Mo=O unit in oxomolybdenum chlorides was found to be responsible for the catalytic NAS profile as supported by a control NAS reaction of using an authentic adduct-MoOCl2(O2-CBu t)2 between pivalic anhydride and MoO2Cl 2 as the catalyst.

Asymmetric syntheses of (R)- and (S)-2-aminobutanesulfonic acid and their 3,3-dimethylderivatives

(R)- and (S)-2-aminobutanesulfonic acid, 3a and 3b, and (R)- and (S)-2-amino-3,3-dimethylbutanesulfonic acid, 4a and 4b, were synthesized from the corresponding N-Boc protected β-amino alcohols in good yields and high enantiomeric purities (> 99% ee).