153864-57-4Relevant articles and documents
Structure Property Analysis of the Solution and Solid-State Properties of Bistable Photochromic Hydrazones
Shao, Baihao,Qian, Hai,Li, Quan,Aprahamian, Ivan
, p. 8364 - 8371 (2020)
The development of new photochromic compounds and the optimization of their photophysical and switching properties are prerequisites for accessing new functions and opportunities that are not possible with currently available systems. To this end we recen
Hydrazone Photoswitches for Structural Modulation of Short Peptides
Ahn, Sangdoo,Jeong, Myeongsu,Kwon, Sunbum,Lee, Kwonjung,Park, Jiyoon,Pramanik, Susnata,Seo, Yejin
supporting information, (2022/02/05)
Molecules that undergo light-driven structural transformations constitute the core components in photoswitchable molecular systems and materials. Among various families of photoswitches, photochromic hydrazones have recently emerged as a novel class of photoswitches with superb properties, such as high photochemical conversion, spectral tunability, thermal stability, and fatigue resistance. Hydrazone photoswitches have been adopted in various adaptive materials at different length scales, however, their utilization for modulating biomolecules still has not been explored. Herein, we present new hydrazone switches that can photomodulate the structures of short peptides. Systematic investigation on a set of hydrazone derivatives revealed that installation of the amide group does not significantly alter the photoswitching behaviors. Importantly, a hydrazone switch comprising an upper phenyl ring and a lower quinolinyl ring was effective for structural control of peptides. We anticipate that this work, as a new milestone in the research of hydrazone switches, will open a new avenue for structural and functional control of biomolecules.
