15443-52-4

Basic information

• Product Name: N-isobutylcyclohexylamine
• Synonyms: N-isobutylcyclohexylamine;Isobutylcyclohexylamine;Einecs 239-457-8
• CAS NO: 15443-52-4
• Molecular Formula: C₁₀H₂₁N
• Molecular Weight: 155.28044
• EINECS: 239-457-8
• Mol File: 15443-52-4.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 200.1°Cat760mmHg
• Flash Point: 65.7°C
• Appearance: /
• Density: 0.84g/cm³
• Vapor Pressure: 0.329mmHg at 25°C
• Refractive Index: 1.454
• PKA: 11.16±0.20(Predicted)
• CAS DataBase Reference: N-isobutylcyclohexylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-isobutylcyclohexylamine(15443-52-4)
• EPA Substance Registry System: N-isobutylcyclohexylamine(15443-52-4)

Safety Data

• Hazardous Substances Data: 15443-52-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H21N/c1-9(2)8-11-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3

Upstream product

• 78-83-1 2-methyl-propan-1-ol 
• 108-91-8 cyclohexylamine 
• 88304-20-5 N-(2-methylpropylidene)cyclohexanamine 
• 19573-22-9 cyclohexyl azide 
• 115-11-7 isobutene 
• 98-95-3 nitrobenzene 
• 78-81-9 isobutylamine 
• 108-95-2 phenol 
• 590-86-3 isovaleraldehyde 
• 4406-41-1 N-phenylisobutyramide 
• 1384953-98-3 C₁₄H₃₁NSi 
• 6282-96-8 2-methyl-N-cyclohexylpropanamide 
• 108-93-0 cyclohexanol 
• 78-84-2 isobutyraldehyde 

Downstream Products

• 14165-25-4 N-Cyclohexyl-N-isobutyl-aethylendiamin 
• 57375-66-3 N-Isopropoxycarbonyl-3-(N-cyclohexyl-N-isobutylcarbamoyloxy)anilin 
• 54041-56-4 [3-(Cyclohexyl-isobutyl-carbamoyloxy)-phenyl]-carbamic acid methyl ester 
• 46814-12-4 <2-(Cyclohexyl-isobutyl-amino)-aethyl>-guanidin 

Relevant articles and documents

Design, synthesis and biological evaluation of 2,5-dimethylfuran-3-carboxylic acid derivatives as potential IDO1 inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) plays a vital role in tumor immune escape and has emerged as a promising target for cancer immunotherapy. In this study, a novel series of 2,5-dimethylfuran-3-carboxylic acid derivatives were designed, synthesized and evaluated for inhibitory activities against IDO1, and their structure-activity relationship was investigated. Among these, compound 19a exhibited excellent IDO1 inhibitory activity (HeLa cellular IC50 = 4.0 nM, THP-1 cellular IC50 = 4.6 nM). Further molecular docking studies revealed that the compound 19a formed a coordinate bond with the heme iron through the carboxylic acid moiety. These results indicate that compound 19a is a potential IDO1 inhibitor for further investigation.

Colloidal and Nanosized Catalysts in Organic Synthesis: XXIII. Reductive Amination of Carbonyl Compounds Catalyzed by Nickel Nanoparticles in a Plug-Flow Reactor

Reductive amination of aldehydes and ketones with primary and secondary amines under catalysis with nickel nanoparticles supported on zeolite X, MgO, or activated carbon in the gas phase or in the gas-liquid system in a plug-flow reactor proceeds at atmospheric pressure of hydrogen with the formation of secondary or tertiary amines in high yield.

Efficient and Selective Hydrosilylation of Secondary and Tertiary Amides Catalyzed by an Iridium(III) Metallacycle: Development and Mechanistic Investigation

Readily accessible cationic IrIII metallacycles catalyze efficiently the chemoselective hydrosilylation of tertiary and secondary amides to amines. The catalyst described herein operates at low loadings using inexpensive 1,1,3,3-tetramethyldisiloxane and allows fast reactions with high yields, selectivities, and turnover numbers. A transient iminium intermediate has been observed for the first time by using mass spectrometry, and the activation of the catalyst and the silane reagent have been studied by using DFT calculations. These fundamental insights support the present and future improvements of IrIII metallacycles through proper ligand modifications and enable further broad applications of catalysts based on metallacycles.