154467-16-0

Basic information

• Product Name: N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate
• Synonyms: N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate;N-(2-AMinoethyl)-4-MorpholinecarboxaMide ethanedio;N-(2-AMinoethyl)-4-MorpholinecarboxaMide;N-(2-aMinoethyl)-4-MorpholinecarboxaMide oxalate;N-(2-AMinoethyl)Morpholine-4-carboxaMide oxalate;Landiolol HCl PI-3
• CAS NO: 154467-16-0
• Molecular Formula: C₂H₂O₄*C₇H₁₅N₃O₂
• Molecular Weight: 263.25
• EINECS: 1308068-626-2
• Mol File: 154467-16-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate(154467-16-0)
• EPA Substance Registry System: N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate(154467-16-0)

Safety Data

• Hazardous Substances Data: 154467-16-0(Hazardous Substances Data)

Usage

General Description

N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate, also known as morpholinylacetamidoethylformate and M89504, is a chemical compound used as an antineoplastic and antiviral agent. It is a derivative of morpholine and has been shown to possess significant antitumor activity in preclinical studies. The compound has also demonstrated potent antiviral activity against human cytomegalovirus and the influenza A virus. N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate is a promising candidate for the development of new cancer and antiviral treatments.

InChI:InChI=1/C7H15N3O2.C2H2O4/c8-1-2-9-7(11)10-3-5-12-6-4-10;3-1(4)2(5)6/h1-6,8H2,(H,9,11);(H,3,4)(H,5,6)

Upstream product

• 144-62-7 oxalic acid 
• 93605-74-4 4-[(1H-imidazol-1-yl)carbonyl]morpholine 
• 107-15-3 ethylenediamine 

Downstream Products

• 133242-30-5 2,2-dimethyl-1,3-dioxolan-4S-ylmethyl 3-<4-<3-<2-(morpholinocarbonylamino)ethylamino>-2S-hydroxypropoxy>phenyl>propionate 
• 144481-98-1 Landiolol hydrochloride 
• 69630-16-6 N-(2-aminoethyl)-4-morpholine carboxamide 
• 1253907-79-7 landiolol hydrochloride 

Relevant articles and documents

Preparation method of landiolol hydrochloride intermediate

The invention discloses a preparation method of a high-purity landiolol hydrochloride intermediate N-(2-aminoethyl)-4-morpholinecarboxamide oxalate. The preparation method comprises the following steps: reacting N-phenoxy carbonyl morpholine with ethylenediamine, concentrating the reaction liquid, adding a solvent for dissolving, adjusting the pH value to 9-14 by using alkali, filtering to remove solid byproducts, concentrating the filtrate to obtain N-(2-aminoethyl)-4-morpholine formamide, adding water for dissolving, adjusting the pH value to 1-6 by using oxalic acid, filtering to remove a small amount of ethylenediamine oxalate solid, concentrating the filtrate, adding a solvent, and recrystallizing to obtain the high-purity N-(2-aminoethyl)-4-morpholinecarboxamide oxalate. According to the method, the high-purity landiolol hydrochloride intermediate can be obtained, the defects that the byproduct sodium phenate is difficult to filter, ethylenediamine is easy to remain and the like are overcome, the process is stable and controllable, the solvent can be recycled, and the method is more suitable for industrial production.