1253907-79-7Relevant articles and documents
Preparation method of landiolol hydrochloride intermediate
-
Paragraph 0026, (2021/06/06)
The invention discloses a preparation method of a high-purity landiolol hydrochloride intermediate N-(2-aminoethyl)-4-morpholinecarboxamide oxalate. The preparation method comprises the following steps: reacting N-phenoxy carbonyl morpholine with ethylenediamine, concentrating the reaction liquid, adding a solvent for dissolving, adjusting the pH value to 9-14 by using alkali, filtering to remove solid byproducts, concentrating the filtrate to obtain N-(2-aminoethyl)-4-morpholine formamide, adding water for dissolving, adjusting the pH value to 1-6 by using oxalic acid, filtering to remove a small amount of ethylenediamine oxalate solid, concentrating the filtrate, adding a solvent, and recrystallizing to obtain the high-purity N-(2-aminoethyl)-4-morpholinecarboxamide oxalate. According to the method, the high-purity landiolol hydrochloride intermediate can be obtained, the defects that the byproduct sodium phenate is difficult to filter, ethylenediamine is easy to remain and the like are overcome, the process is stable and controllable, the solvent can be recycled, and the method is more suitable for industrial production.
Method for preparing landiolol hydrochloride
-
Paragraph 0031; 0045-0047, (2019/12/02)
The invention belongs to the field of pharmaceutical chemicals, and particularly relates to an improved method for preparing landiolol and a compound shown as a formula 8. The compound shown as the formula 8 is prepared by reacting a compound shown as a formula 7 with AH (organic amine). The invention also relates to compounds of general formula 7.
Preparation method of landiolol hydrochloride
-
Paragraph 0066-0068; 0073, (2018/11/22)
The invention relates to a preparation method of landiolol hydrochloride, in particular to the selection of a reaction solvent 1,4-dioxane. The landiolol hydrochloride prepared by means of the methodcan prevent the generation of ester exchange impurities, the operation is simple, the reaction yield is high, the method is suitable for industrial large-scale production, and a crude drug and the preparation of the crude drug have better safety performance, effectiveness and stability, and have significant use in preparing drugs used for urgently treating arrhythmia and postoperative dynamic monitoring abnormality.