1548-72-7

Basic information

• Product Name: Benzene, 1-nitro-3-[(trifluoromethyl)sulfonyl]-
• CAS NO: 1548-72-7
• Molecular Formula: C7H4F3NO4S
• Molecular Weight: 255.174
• Mol File: 1548-72-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 1-nitro-3-[(trifluoromethyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-nitro-3-[(trifluoromethyl)sulfonyl]-(1548-72-7)
• EPA Substance Registry System: Benzene, 1-nitro-3-[(trifluoromethyl)sulfonyl]-(1548-72-7)

Safety Data

• Hazardous Substances Data: 1548-72-7(Hazardous Substances Data)

Upstream product

• 349-78-0 3-nitrobenzene-1-sulfonyl fluoride 
• 754-25-6 trimethyl(trifluoromethyl)tin 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 887144-94-7 Togni's reagent II 
• 15898-46-1 sodium 3-nitrobenzenesulfinate 
• 426-58-4 (trifluoromethylsulfonyl)benzene 
• 2926-29-6 Langlois reagent 
• 99-09-2 3-nitro-aniline 
• 456-56-4 phenyl trifluoromethylsulfide 
• 370-47-8 (3-nitrophenyl)(trifluoromethyl)sulfane 

Downstream Products

• 426-59-5 (3-aminophenyl)trifluoromethyl sulfone 

Relevant articles and documents

A convenient route to aryl trifluoromethyl sulfones by fluoride-catalyzed cross-coupling of arenesulfonyl fluorides with (trifluoromethyl)trimethylsilane and (trifluoromethyl)trimethylstannane

Trifluoromethylsulfonyl substituted aromatic compounds 3a-d are prepared from the corresponding sulfonyl fluorides 1a-d by reacting with (trifluoromethyl)trimethylsilane (or-stannane) in the presence of a base under mild conditions in high yields.

Copper-Promoted Trifluoromethanesulfonylation and Trifluoromethylation of Arenediazonium Tetrafluoroborates with NaSO2CF3

A tunable chemoselective trifluoromethanesulfonylation and trifluoromethylation of arenediazonium tetrafluoroborates with Langlois' reagent (NaSO2CF3) was developed. The Cu2O-catalyzed reaction in DMSO gave aryl trifluoromethanesulfones as the major products. On the other hand, the trifluoromethylated arenes were produced in the presence of oxidant tert-butyl hydroperoxide, CuBF4(MeCN)4, and 2,2′;6′,2 terpyridine (tpy). Both of these transformations proceed under mild conditions and tolerate functional groups.

Convenient one-pot procedure for converting aryl sulfides to nitroaryl sulfones

When treated with nitrogen dioxide and ozone in inert solvent at 0°C or below, aryl sulfides underwent smooth oxidative nitration to give nitroaryl sulfones in good yield. Using this methodology, a series of mono- and di-nitrated aryl sulfones were prepared from methyl phenyl sulfide and diphenyl sulfide and their physical data are presented.