349-78-0

Basic information

• Product Name: 3-NITROBENZENESULPHONYL FLUORIDE 97
• Synonyms: 3-NITROBENZENESULPHONYL FLUORIDE 97;m-nitrobenzenesulphonyl fluoride;3-Nitrobenzenesulphonyl fluoride 97%;3-Nitrobenzenesulfonyl fluoride
• CAS NO: 349-78-0
• Molecular Formula: C₆H₄FNO₄S
• Molecular Weight: 205.1636632
• EINECS: 206-492-5
• Mol File: 349-78-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 263.2°Cat760mmHg
• Flash Point: 113°C
• Appearance: /
• Density: 1.493g/cm³
• Vapor Pressure: 0.0171mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: 3-NITROBENZENESULPHONYL FLUORIDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITROBENZENESULPHONYL FLUORIDE 97(349-78-0)
• EPA Substance Registry System: 3-NITROBENZENESULPHONYL FLUORIDE 97(349-78-0)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 349-78-0(Hazardous Substances Data)

Usage

General Description

3-Nitrobenzenesulphonyl Fluoride 97% is a chemical compound also known as 3-nitrobenzenesulfonyl fluoride or 3-Nitrobenzenesulfonic acid fluoride. It has the formula C6H4NO5SF, which indicates that it contains carbon, hydrogen, nitrogen, oxygen, sulfur and fluorine. 3-NITROBENZENESULPHONYL FLUORIDE 97 is known to have an assay percent ranging from 97%. It's used in various applications, primarily as a reagent in organic synthesis allowing the introduction of the nitrobenzenesulfonyl (Nosyl) group. The Nosyl group is often used as a protective group for amines in organic chemistry. It is important to handle the 3-Nitrobenzenesulphonyl Fluoride 97% with care due to its potential reactivity and the risks associated with exposure to toxic chemicals.

InChI:InChI=1/C6H4ClFO2S/c7-11(9,10)6-3-1-5(8)2-4-6/h1-4H

Upstream product

• 368-43-4 phenylsulfonyl fluoride 
• 51516-96-2 3-nitrophenylhydrazine hydrochloride 
• 586-36-7 3-nitrophenyldiazonium tetrafluoroborate 
• 127-68-4 sodium 3-nitrobenzenesulfonate 
• 2613-26-5 3-nitrophenylsulfur pentafluoride 
• 2557-81-5 pentafluorosulfanylbenzene 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 15898-46-1 sodium 3-nitrobenzenesulfinate 
• 121-51-7 3-nitrobenzenesulphonyl chloride 
• 121-52-8 3-nitrophenylsulfonamide 

Downstream Products

• 1548-72-7 1-nitro-3-(trifluoromethylsulfonyl)benzene 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 1547-91-7 3-fluorobenzenesulfonyl fluoride 
• 121-51-7 3-nitrobenzenesulphonyl chloride 
• 121-52-8 3-nitrophenylsulfonamide 
• 4431-74-7 3-amino benzenesulfonyl chloride 
• 368-50-3 3-amino-benzenesulfonyl fluoride 
• 2489-52-3 3-(fluorosulfonyl)benzenesulfonyl chloride 

Relevant articles and documents

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Arenesulfonyl Fluoride Synthesis via Copper-free Sandmeyer-type Fluorosulfonylation of Arenediazonium Salts

The limited availability of highly valuable arenesulfonyl fluorides seriously hinders their further application in many research fields including medicinal chemistry and chemical biological, organic synthesis, polymer preparation, etc. We report herein a mild and efficient copper-free Sandmeyer-type fluorosulfonylation reaction of various arenediazonium salts to prepare valuable arenesulfonyl fluorides using K2S2O5 as both a reductant and a practical sulfonyl source in combination with N-fluorobenzenesulfonimide as an effective fluorine source. This methodology provides an attractive route to diverse important arenesulfonyl fluorides given the overall practicality and scope.

Facile one-pot synthesis of sulfonyl fluorides from sulfonates or sulfonic acids

A facile cascade process for directly transforming the abundant and inexpensive sulfonates (or sulfonic acids) to the highly valuable sulfonyl fluorides was developed. This new protocol features mild reaction conditions using readily available and easy-to-operate reagents. A diverse set of sulfonyl fluorides was prepared facilitating the enrichment of the sulfonyl fluoride library.