15489-90-4 Usage
Description
HEMATIN, also known as the hydroxide of heme, is a bluish-black or brownish pigment compound produced from red blood cells. It is derived from hemoglobin by removing the protein part and oxidizing the iron atom from ferrous Fe2+ to the ferric Fe3+ state, which does not combine with oxygen. HEMATIN plays a crucial role in the formation of cytochromes and peroxidases in the cell and is effective in inhibiting the synthesis of porphyrin while stimulating the synthesis of globin.
Uses
Used in Pharmaceutical Industry:
HEMATIN is used as a pharmaceutical agent for the treatment of porphyria, a condition characterized by the accumulation of heme precursors, porphyrins. It can be administered intravenously to halt the attack of acute porphyria and functions in the liver to accelerate the production of heme, thereby preventing the further accumulation of porphyrins and alleviating the symptoms of porphyria.
Used in Research and Diagnostics:
HEMATIN is used as an indicator and biological stain in various research and diagnostic applications. It has been utilized in studies to test in vitro activities of Rx-01 oxazolidinones against hospital and community pathogens, as well as in studies to test in-vitro bacterial identification using fluorescence spectroscopy with an optical fiber system.
Chemical Properties:
HEMATIN is characterized by its dark crystal structure with a metallic luster.
References
https://en.wikipedia.org/wiki/Haematin
http://house.wikia.com/wiki/Hematin
https://en.oxforddictionaries.com/definition/us/hematin
http://medical-dictionary.thefreedictionary.com/hematin
Purification Methods
Crystallise it from pyridine. Dry it at 40o in vacuo.[Beilstein 26 III/IV 3047.]
Check Digit Verification of cas no
The CAS Registry Mumber 15489-90-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,4,8 and 9 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 15489-90:
(7*1)+(6*5)+(5*4)+(4*8)+(3*9)+(2*9)+(1*0)=134
134 % 10 = 4
So 15489-90-4 is a valid CAS Registry Number.
InChI:InChI=1/C34H34N4O4.Fe.H2O/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);;1H2/q;+2;/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;
15489-90-4Relevant articles and documents
Alkoxide coordination of iron(III) protoporphyrin IX by antimalarial quinoline methanols: A key interaction observed in the solid-state and solution
Gildenhuys, Johandie,Sammy, Chandre J.,Müller, Ronel,Streltsov, Victor A.,Le Roex, Tanya,Kuter, David,De Villiers, Katherine A.
, p. 16767 - 16777 (2015/10/06)
The quinoline methanol antimalarial drug mefloquine is a structural analogue of the Cinchona alkaloids, quinine and quinidine. We have elucidated the single crystal X-ray diffraction structure of the complexes formed between racemic erythro mefloquine and ferriprotoporphyrin IX (Fe(iii)PPIX) and show that alkoxide coordination is a key interaction in the solid-state. Mass spectrometry confirms the existence of coordination complexes of quinine, quinidine and mefloquine to Fe(iii)PPIX in acetonitrile. The length of the iron(iii)-O bond in the quinine and quinidine complexes as determined by Extended X-ray Absorption Fine Structure (EXAFS) spectroscopy unequivocally confirms that coordination of the quinoline methanol compounds to Fe(iii)PPIX occurs in non-aqueous aprotic solution via their benzylic alkoxide functional group. UV-visible spectrophotometric titrations of the low-spin bis-pyridyl-Fe(iii)PPIX complex with each of the quinoline methanol compounds results in the displacement of a single pyridine molecule and subsequent formation of a six-coordinate pyridine-Fe(iii)PPIX-drug complex. We propose that formation of the drug-Fe(iii)PPIX coordination complexes is favoured in a non-aqueous environment, such as that found in lipid bodies or membranes in the malaria parasite, and that their existence may contribute to the mechanism of haemozoin inhibition or other toxicity effects that lead ultimately to parasite death. In either case, coordination is a key interaction to be considered in the design of novel antimalarial drug candidates.
