155505-55-8Relevant articles and documents
Internal resin capture - A self purification method for the synthesis of C-terminally modified peptides
Davies, Michael,Bradley, Mark
, p. 4733 - 4746 (1999)
A synthetic strategy which allows for the general modification of peptides at the C-terminus has long been the goal of the synthetic chemist. We report here the full synthetic details of our inversion and modification methodology demonstrating the method with the synthesis of peptide amides, alcohols, nitriles and a range of other modified peptides.
Optimising inhibitors of trypanothione reductase using solid-phase chemistry
Chitkul, Bordin,Bradley, Mark
, p. 2367 - 2369 (2007/10/03)
A series of inhibitors of the enzyme trypanothione reductase has been identified using directed solid-phase chemistry. The compounds were based on a series of polyamine scaffolds and used the natural product kukoamine A as the lead structure. A compound with a K(i) of 76 nM was identified, although somewhat surprisingly the compound appeared to be noncompetitive in nature. (C) 2000 Elsevier Science Ltd.