313983-92-5Relevant articles and documents
Optimising inhibitors of trypanothione reductase using solid-phase chemistry
Chitkul, Bordin,Bradley, Mark
, p. 2367 - 2369 (2007/10/03)
A series of inhibitors of the enzyme trypanothione reductase has been identified using directed solid-phase chemistry. The compounds were based on a series of polyamine scaffolds and used the natural product kukoamine A as the lead structure. A compound with a K(i) of 76 nM was identified, although somewhat surprisingly the compound appeared to be noncompetitive in nature. (C) 2000 Elsevier Science Ltd.