1561811-45-7

Basic information

• Product Name: N-[5-(chloromethyl)-2-methylphenyl]-5-({4-[4-(trifluoromethoxy)phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)pyridine-2-carboxamide
• Synonyms: N-[5-(chloromethyl)-2-methylphenyl]-5-({4-[4-(trifluoromethoxy)phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)pyridine-2-carboxamide
• CAS NO: 1561811-45-7
• Molecular Weight: 552.943
• Mol File: 1561811-45-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[5-(chloromethyl)-2-methylphenyl]-5-({4-[4-(trifluoromethoxy)phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)pyridine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[5-(chloromethyl)-2-methylphenyl]-5-({4-[4-(trifluoromethoxy)phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)pyridine-2-carboxamide(1561811-45-7)
• EPA Substance Registry System: N-[5-(chloromethyl)-2-methylphenyl]-5-({4-[4-(trifluoromethoxy)phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)pyridine-2-carboxamide(1561811-45-7)

Safety Data

• Hazardous Substances Data: 1561811-45-7(Hazardous Substances Data)

Upstream product

• 4513-94-4 1H-pyrrole-2-carbonitrile 
• 1561810-14-7 2-chloro-4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazine 
• 918538-05-3 2,4-dichloro-pyrrolo[2,1-f][1,2,4]triazine 
• 918538-04-2 pyrrolo[2,1-f][1,2,4]triazine-2,4(1H, 3H)-dione 
• 1379337-32-2 1-(ethoxyformamido)-1H-pyrrole-2-carboxamide 
• 159326-69-9 1-aminopyrrole-2-carboxamide 
• 159326-66-6 N-amino-1H-pyrrole-2-carbonitrile 
• 1561811-36-6 N-[5-(hydroxymethyl)-2-methylphenyl]-5-({4-[4-(trifluoromethoxy)phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)pyridine-2-carboxamide 
• 1561811-30-0 5-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxylic acid 

Downstream Products

• 1561811-03-7 N-{2-methyl-5-[(morpholinyl)methyl]phenyl}-5-({4-[4-(trifluoromethoxy)phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)pyridine-2-carboxamide 

Relevant articles and documents

Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors

A novel series of Hh signaling pathway inhibitors were designed by replacing the pyrimidine skeleton of our earlier reported lead compound 1 with pyrrolo[2,1-f][1,2,4]triazine scaffold. Starting from this new scaffold, SAR exploration was investigated based on structural modification on A-ring, C-ring and D-ring. And several much potent compounds were studies in vivo to profile their pharmacokinetic properties. Finally, optimization leads to the identification of compound 19a, a potent Hh signaling pathway inhibitor with superior potency in vitro and satisfactory pharmacokinetic properties in vivo.