157671-99-3

Basic information

• Product Name: 2-(4-fluorophenyl)-1-[2-[4-(methylsulfonyl)phenyl]-2-oxoethoxy]ethanone
• Synonyms: 2-(4-fluorophenyl)-1-[2-[4-(methylsulfonyl)phenyl]-2-oxoethoxy]ethanone
• CAS NO: 157671-99-3
• Molecular Weight: 350.368
• Mol File: 157671-99-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-1-[2-[4-(methylsulfonyl)phenyl]-2-oxoethoxy]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-1-[2-[4-(methylsulfonyl)phenyl]-2-oxoethoxy]ethanone(157671-99-3)
• EPA Substance Registry System: 2-(4-fluorophenyl)-1-[2-[4-(methylsulfonyl)phenyl]-2-oxoethoxy]ethanone(157671-99-3)

Safety Data

• Hazardous Substances Data: 157671-99-3(Hazardous Substances Data)

Upstream product

• 100-68-5 methyl-phenyl-thioether 
• 50413-24-6 2-bromo-1-(4-methanesulfonylphenyl)ethanone 
• 98-86-2 acetophenone 
• 10297-73-1 4-(methanesulfonyl)acetophenone 
• 1778-09-2 4-(Methylthio)acetophenone 
• 405-50-5 p-Fluorophenylacetic acid 
• 21382-98-9 p-cyanophenyl methyl sulfide 

Downstream Products

• 179174-91-5 2-(4-fluorophenyl)-3-<4-(methylsulfonyl)phenyl>-1,4-dihydroxy-2-butene 
• 168299-83-0 4-[6-(4-fluorophenyl)spiro[2.4]hept-5-en-5-yl]benzenesulfonamide 
• 168433-84-9 SC-58451 
• 168299-84-1 1-<2-(4-fluorophenyl)-4,4-bis(tosylmethyl)cyclopenten-1-yl>-4-(methylsulfonyl)benzene 
• 159429-83-1 1-<2-(4-fluorophenyl)-4,4-dicarbomethoxycyclopenten-1-yl>-4-(methylsulfonyl)benzene 
• 168299-81-8 1-<2-(4-fluorophenyl)-4,4-bis(hydroxymethyl)cyclopenten-1-yl>-4-(methylsulfonl)benzene 
• 157672-00-9 3-(4-fluorophenyl)-4-<4-(methylsulfonyl)phenyl>-5H-furan-2-one 

Relevant articles and documents

Stereoselective synthesis and anti-proliferative effects on prostate cancer evaluation of 5-substituted-3,4-diphenylfuran-2-ones

Series of 5-substituted-3,4-diphenylfuran-2-ones were stereoselectively prepared. Their potential anti-proliferative effects on prostate cancer and some of their cyclooxygenases (COXs) inhibitory activities were evaluated. Structure-activity relationship (SAR) data, acquired by substituent modification at the para-position and ortho-position of the C-3 phenyl ring and 5-substituted modification of the central furanone, showed that 3-(2-chloro-phenyl)-4-(4-methanesulfonyl-phenyl)-5-(1-methoxy-ethyl) -5H-furan-2-one (13p) was the most potent compound and could effectively reduce the proliferation of prostate cancer cells (PC3 cell IC50 = 20 μM; PC3 PCDNA cell IC50 = 5 μM; PC3 SKP2 cell IC50 = 5 μM; DU145 cell IC50 = 25 μM). The cell cycle analysis for 13p in DU145 indicated that 13p may induce G1 phase arrest.

Method of preparing sulfmonamides from sulfones

A one-pot synthesis of sulfonamides from sulfones has been developed. Conversion of sulfones to the corresponding sulfinic acid salts is followed by oxidative-amination to give the sulfonamides.

Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: Synthesis and structure-activity relationships

A novel series of 5,6-diarylspiro[2.4]hept-5-enes was shown to provide highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. A study of structure-activity relationships in this series suggests that 3,4- disubstituted phenyl analogs are generally more selective than 4-substituted phenyl analogs and that replacement of the methyl sulfone group on the 6- phenyl ring with a sulfonamide moiety results in compounds with superior in vivo pharmacological properties, although with lower COX-2 selectivity. Several compounds have been shown to possess promising pharmacological properties in adjuvant-induced arthritis and edema analgesia models. The absence of gastrointestinal (GI) toxicity at 200 mpk of several selected compounds in rats and mice corresponds well with the weak potency for inhibition of COX-1 observed in the enzyme assay. Methyl sulfone 55 and sulfonamide 24 were shown to have superior in vivo pharmacological profiles, low GI toxicity, and good oral bioavailability and duration of action.