158144-38-8

Basic information

• Product Name: 4,4-dimethyl-2-(4'-tetrahydropyranyloxymethylbiphenyl-2-yl)oxazoline
• Synonyms: 4,4-dimethyl-2-(4'-tetrahydropyranyloxymethylbiphenyl-2-yl)oxazoline
• CAS NO: 158144-38-8
• Molecular Weight: 365.472
• Mol File: 158144-38-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,4-dimethyl-2-(4'-tetrahydropyranyloxymethylbiphenyl-2-yl)oxazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-dimethyl-2-(4'-tetrahydropyranyloxymethylbiphenyl-2-yl)oxazoline(158144-38-8)
• EPA Substance Registry System: 4,4-dimethyl-2-(4'-tetrahydropyranyloxymethylbiphenyl-2-yl)oxazoline(158144-38-8)

Safety Data

• Hazardous Substances Data: 158144-38-8(Hazardous Substances Data)

Upstream product

• 57598-33-1 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline 

Downstream Products

• 114772-38-2 Methyl 4'-(bromomethyl)biphenyl-2-carboxylate 
• 158144-53-7 4,4-dimethyl-2-[4'-(p-toluenesulfonyloxymethyl)biphenyl-2-yl)oxazoline 
• 158144-57-1 methyl 2-(4'-p-toluenesulfonyloxymethylphenyl)benzoate 
• 158144-55-9 methyl 4'-(hydroxymethyl)biphenyl-2-carboxylate 
• 158144-54-8 4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carboxylic acid 

Relevant articles and documents

Process for the preparation of imidazopyridine derivatives, and intermediates therefore

The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin II receptor useful as an antihypertensive drug, a biphenyl derivative which is a precursor of the substituent of the pyridine derivative, a process for the preparation thereof, and an intermediate useful for the preparation of the biphenyl derivative: STR1 The 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo-[4,5-b]pyridine derivative can be prepared in a high yield according to the present invention from a 2-amino-5-halogeno-3-nitropyridine derivative through amidation, N-alkylation and reductive cyclization. The halogen atom introduced at the 5-position as a protective group against nitration can be eliminated simultaneously in the step which is conducted thereafter. Thus, this process is industrially advantageous.Further, the biphenyl derivative of the present invention is excellent in reactivity and purity of the product, thus being an intermediate suitable for the industrial production.