158144-54-8 Usage
Description
4'-(Hydroxymethyl)-[1,1'-Biphenyl]-2-Carboxylic Acid, also known as 2-[4-(Hydroxymethyl)phenyl]benzoic Acid, is an organic compound with the molecular formula C13H12O3. It features a biphenyl core with a hydroxymethyl group attached to the 4' position and a carboxylic acid group at the 2 position. This molecule is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural features.
Uses
Used in Pharmaceutical Industry:
4'-(Hydroxymethyl)-[1,1'-Biphenyl]-2-Carboxylic Acid is used as an intermediate in the synthesis of various pharmaceutical compounds. Its ability to form hydroxylated arenes makes it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Synthesis of Telmisartan:
In the pharmaceutical industry, 4'-(Hydroxymethyl)-[1,1'-Biphenyl]-2-Carboxylic Acid is used as an intermediate or impurity in the production of Telmisartan (T017000). Telmisartan is an angiotensin II receptor antagonist used to treat hypertension and cardiovascular diseases. The compound plays a crucial role in the synthesis process, contributing to the development of this important class of drugs.
Used in Chemical Industry:
4'-(Hydroxymethyl)-[1,1'-Biphenyl]-2-Carboxylic Acid can also be utilized in the chemical industry for the synthesis of various hydroxylated arenes. These arenes can serve as key intermediates in the production of a wide range of chemical products, including dyes, pigments, and other specialty chemicals. The versatility of this compound makes it a valuable asset in the development of new materials and applications across various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 158144-54-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,1,4 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 158144-54:
(8*1)+(7*5)+(6*8)+(5*1)+(4*4)+(3*4)+(2*5)+(1*4)=138
138 % 10 = 8
So 158144-54-8 is a valid CAS Registry Number.
158144-54-8Relevant articles and documents
Process for the preparation of imidazopyridine derivatives, and intermediates therefore
-
, (2008/06/13)
The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin II receptor useful as an antihypertensive drug, a biphenyl derivative which is a precursor of the substituent of the pyridine derivative, a process for the preparation thereof, and an intermediate useful for the preparation of the biphenyl derivative: STR1 The 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo-[4,5-b]pyridine derivative can be prepared in a high yield according to the present invention from a 2-amino-5-halogeno-3-nitropyridine derivative through amidation, N-alkylation and reductive cyclization. The halogen atom introduced at the 5-position as a protective group against nitration can be eliminated simultaneously in the step which is conducted thereafter. Thus, this process is industrially advantageous.Further, the biphenyl derivative of the present invention is excellent in reactivity and purity of the product, thus being an intermediate suitable for the industrial production.
