1584301-56-3

Basic information

• Product Name: 5-(2,4-dihydroxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide
• Synonyms: 5-(2,4-dihydroxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide
• CAS NO: 1584301-56-3
• Molecular Weight: 373.409
• Mol File: 1584301-56-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(2,4-dihydroxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,4-dihydroxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide(1584301-56-3)
• EPA Substance Registry System: 5-(2,4-dihydroxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide(1584301-56-3)

Safety Data

• Hazardous Substances Data: 1584301-56-3(Hazardous Substances Data)

Upstream product

• 1184181-48-3 2,4-dihydroxy-5- isopropylbenzoic acid 
• 1584301-48-3 ethyl 5-(2,4-dihydroxy-5-isopropylbenzoyl)-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxylate 
• 75-04-7 ethylamine 
• 1584301-40-5 C₁₀H₁₂N₂O₄ 
• 104916-29-2 1-Acetyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydro-pyridine 
• 32161-06-1 1-acetyl-4-piperidinone 
• 1584301-51-8 N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide 

Downstream Products

• 1584301-65-4 5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide 

Relevant articles and documents

Exploring in vitro and in vivo Hsp90 inhibitors activity against human protozoan parasites

A set of compounds, previously selected as potent Hsp90α inhibitors, has been studied on a panel of human parasites. 5-Aryl-3,4-isoxazolediamide derivatives (1) were active against two protozoa, Trypanosoma brucei rhodesiense and Plasmodium falciparum, with a good tolerability toward cytotoxicity on non-malignant L6 rat myoblast cell line, unlike the 1,5-diaryl,4-carboxamides-1,2,3-triazole derivatives (2) which, while showing a single-digit nM range activity against the same protozoa, were also highly cytotoxic on L6 cells. In a subsequent in vivo study, two isoxazolediamide derivatives, 1a and 1b, were very efficacious on the sleeping sickness-causing agent with a clear parasitaemia during treatment. These data, however, showed that not all protozoa are sensitive to Hsp90 inhibitors, as well as not all Hsp90 inhibitors are equally active on parasites.