1584301-65-4

Basic information

• Product Name: 5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide
• Synonyms: 5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide
• CAS NO: 1584301-65-4
• Molecular Weight: 457.483
• Mol File: 1584301-65-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide(1584301-65-4)
• EPA Substance Registry System: 5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide(1584301-65-4)

Safety Data

• Hazardous Substances Data: 1584301-65-4(Hazardous Substances Data)

Upstream product

• 1584301-56-3 5-(2,4-dihydroxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide 
• 108-24-7 acetic anhydride 
• 1184181-48-3 2,4-dihydroxy-5- isopropylbenzoic acid 
• 1584301-51-8 N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide 
• 32161-06-1 1-acetyl-4-piperidinone 
• 104916-29-2 1-Acetyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydro-pyridine 
• 1584301-40-5 C₁₀H₁₂N₂O₄ 

Relevant articles and documents

4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors

Hsp90 is considered an interesting therapeutic target for anticancer drug development. Here we describe a new class of 4,5,6,7-tetrahydro-isoxazolo-[4,5- c]-pyridine compounds. A small library of derivatives has been synthesized and investigated. Some reported compounds show interesting properties combining both notable binding to Hsp90 and potent cell growth inhibitory activity. N-5 substitution with a 2,4 resorcinol carboxamide appears crucial for activity. Moreover, a derivative bearing a hydroxamic acid residue bound to C-3 amide portion was found to inhibit both Hsp90 and HDAC6.