158792-24-6 Usage
Description
Collismycin A is a rare and unusual antibiotic belonging to the caerulomycin class, characterized by a core 2,2’-bispyridyl with an oxime substituent. It is produced by a strain of Streptomyces and was discovered by researchers from Kirin, Japan in 1994. Collismycin A is known for its potent inhibition of glucocorticoid receptor binding and has demonstrated weak to moderate activity against bacteria, fungi, and tumor cell lines. More recently, it has been recognized as a potent and selective neuroprotective agent against oxidative stress, with potential applications in the development of related analogues for various industries.
Uses
Used in Pharmaceutical Industry:
Collismycin A is used as an anti-proliferative agent for its activity against cancer cells, making it a promising candidate for the development of novel cancer treatments.
Used in Neuroprotection:
Collismycin A is used as a potent and selective neuroprotective agent for its ability to protect against oxidative stress, which can be beneficial in the treatment and prevention of neurodegenerative diseases.
Used in Iron Chelation:
Collismycin A is used as an iron chelator, which can help in the development of neuroprotective compounds by reducing the harmful effects of excess iron in the brain.
Used in Biosynthesis Research:
Collismycin A is used as a starting point for the biosynthesis of related analogues, which can potentially lead to the discovery of new compounds with improved properties and applications in various industries, including pharmaceuticals and biotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 158792-24-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,7,9 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 158792-24:
(8*1)+(7*5)+(6*8)+(5*7)+(4*9)+(3*2)+(2*2)+(1*4)=176
176 % 10 = 6
So 158792-24-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H13N3O2S/c1-18-12-7-10(9-5-3-4-6-14-9)16-11(8-15-17)13(12)19-2/h3-8,16H,1-2H3/b11-8+
158792-24-6Relevant articles and documents
Generation by mutasynthesis of potential neuroprotectant derivatives of the bipyridyl collismycin A
Sialer, Carlos,Garcia, Ignacio,Gonzalez-Sabin, Javier,Brana, Alfredo F.,Mendez, Carmen,Moris, Francisco,Salas, Jose A.
, p. 5707 - 5709 (2013)
Collismycin A is a member of the 2,2′-bipyridyl family of natural products and structurally belongs to the hybrid polyketides-nonribosomal peptides. A gene coding for a lysine 2-aminotransferase of Streptomyces sp. CS40 (collismycin A producer) was inactivated by gene replacement. The mutant was unable of synthesizing collismycin A but it recovered this capability when picolinic acid was added to the culture medium. By feeding different picolinic acid analogs to this mutant, two new collismycin A derivatives were obtained with a methyl group at the 4 and 6 position of the first pyridine ring of collismycin A, respectively. The two compounds showed effective neuroprotective action against an oxidative stress inducer in a zebra fish model, one of them showing higher neuroprotectant activity than that of collismycin A and that of the control lipoic acid.
First Syntheses of Caerulomycin E and Collismycins A and C. A New Synthesis of Caerulomycin A
Trécourt, Fran?ois,Gervais, Bruno,Mongin, Olivier,Gal, Catherine Le,Mongin, Florence,Quéguiner, Guy
, p. 2892 - 2897 (2007/10/03)
Caerulomycins produced by Streptomyces caeruleus, and collismycins more recently isolated from Streptomyces species, are bipyridinic molecules endowed with antibiotic and cytotoxic activities. The first syntheses of caerulomycin E (1), as well as new synt