159183-36-5

Basic information

• Product Name: tert-butyl (S)-N-[2-(4-aminophenyl)ethyl]-N-(2-hydroxy-3-phenoxy)propylcarbamate
• Synonyms: tert-butyl (S)-N-[2-(4-aminophenyl)ethyl]-N-(2-hydroxy-3-phenoxy)propylcarbamate
• CAS NO: 159183-36-5
• Molecular Weight: 386.491
• Mol File: 159183-36-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: tert-butyl (S)-N-[2-(4-aminophenyl)ethyl]-N-(2-hydroxy-3-phenoxy)propylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (S)-N-[2-(4-aminophenyl)ethyl]-N-(2-hydroxy-3-phenoxy)propylcarbamate(159183-36-5)
• EPA Substance Registry System: tert-butyl (S)-N-[2-(4-aminophenyl)ethyl]-N-(2-hydroxy-3-phenoxy)propylcarbamate(159183-36-5)

Safety Data

• Hazardous Substances Data: 159183-36-5(Hazardous Substances Data)

Upstream product

• 24954-67-4 2-(p-nitrophenyl)ethylamine 
• 29968-78-3 2-(4-nitrophenyl)ethylamine monohydrochloride 
• 108-95-2 phenol 
• 202740-27-0 (S)-1-{[2-(4-nitrophenyl)ethyl]amino}-3-phenoxypropan-2-ol 
• 71031-03-3 (R)-phenyl glycidyl ether 
• 24424-99-5 di-tert-butyl dicarbonate 
• 202740-28-1 tert-butyl (S)-N-(2-hydroxy-3-phenoxy)propyl-N-[2-(4-nitrophenyl)ethyl]carbamate 

Downstream Products

• 391901-50-1 tert-butyl 4-[(2,4-dioxo-1,3-thiazolidin-5-yl)amino]phenethyl[(2 S)-2-hydroxy-3-phenoxypropyl]carbamate 
• 1395068-68-4 tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-[2-(4-{[2-(2-methanesulfonylaminothiazol-4-yl)acetyl]amino}phenyl)ethyl]carbamate 
• 211103-25-2 tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-[2-(4-{[2-(2-phenylaminothiazol-4-yl)acetyl]amino}phenyl)ethyl]carbamate 
• 1395068-66-2 tert-butyl (S)-N-[2-(4-{[2-(2-acetylaminothiazol-4-yl)acetyl]amino}phenyl)ethyl]-N-(2-hydroxy-3-phenoxypropyl)carbamate 
• 211103-92-3 (S)-2-(2-acetylaminothiazol-4-yl)-4'-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}acetanilide hydrochloride 
• 1395069-05-2 tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[2-(4-isopropylphenylamino)thiazol-4-yl]acetyl}amino)-phenyl]ethyl}carbamate 
• 211102-63-5 (S)-4'-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}-2-[(4-methoxyphenylamino)thiazol-4-yl]acetanilide hydrochloride 
• 1395069-04-1 tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[2-(4-methoxyphenylamino)thiazol-4-yl]acetyl}amino)phenyl]ethyl}carbamate 
• 211103-81-0 (S)-4'-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}-2-[(4-nitrophenylamino)thiazol-4-yl]acetanilide hydrochloride 
• 1395069-03-0 tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[2-(4-nitrophenylamino)thiazol-4-yl]acetyl}amino)phenyl]ethyl}carbamate 
• 1395069-02-9 tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[2-(4-trifluoromethylphenylamino)thiazol-4-yl]acetyl}amino)phenyl]ethyl}carbamate 
• 211102-62-4 (S)-2-[(4-chlorophenylamino)thiazol-4-yl]-4-'{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}acetanilide hydrochloride 
• 1395069-01-8 tert-butyl (S)-N-{2-[4-({2-[2-(4-chlorophenylamino)-thiazol-4-yl]acetyl}amino)phenyl]ethyl}-N-(2-hydroxy-3-phenoxypropyl)carbamate 
• 211103-30-9 tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[2-(3-methoxyphenylamino)thiazol-4-yl]acetyl}amino)phenyl]ethyl}carbamate 

Relevant articles and documents

Chemoselective and Kilogram-Scale Synthesis of Acetanilide β3-Adrenergic Receptor Agonist

We describe an alternative route for the synthesis of β3-adrenergic receptor agonist (S)-2-(2-phenylamino-1,3- thiazol-4-yl)-4′-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}acetanilide (1). The key intermediate (S)-1-{[2-(4-aminophenyl)ethyl]amin

Discovery of a novel, potent and selective human β3- adrenergic receptor agonist

Design and structure-activity relationships of a novel β3- adrenergic receptor agonist are described. The discovery of a novel, potent and selective β3-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the struc

Potent, selective aminothiazolidinediones agonists of the human β3 Adrenergic receptor

A cloned human β3 adrenergic receptor assay was used to identify potent and selective β3 agonists. The thiazolidinedione moiety has been identified as a new pharmacophore for the human β3 adrenergic receptor. The versatility of the thiazolidinedione pharmacophore was demonstrated in both the arylethanolamine and phenylpropanolamine families of β3 agonists, where potent and selective compounds have been synthesized. Thiazolidinedione 20, a potent and selective human β3 agonist, increased thermogenesis and lowered plasma glucose levels in the db/db mice.