15925-18-5

Basic information

• Product Name: 2,2-DiMethyl-1-propanaMine hydrochloride
• Synonyms: 2,2-DiMethyl-1-propanaMine hydrochloride;2,2-DiMethylpropan-1-aMine hydrochloride;2,2-Dimethylpropylamine hydrochloride
• CAS NO: 15925-18-5
• Molecular Formula: C₅H₁₃N*ClH
• Molecular Weight: 123.62436
• EINECS: -0
• Mol File: 15925-18-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 294-296℃
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,2-DiMethyl-1-propanaMine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DiMethyl-1-propanaMine hydrochloride(15925-18-5)
• EPA Substance Registry System: 2,2-DiMethyl-1-propanaMine hydrochloride(15925-18-5)

Safety Data

• Hazardous Substances Data: 15925-18-5(Hazardous Substances Data)

Usage

General Description

2,2-DiMethyl-1-propanaMine hydrochloride, also known as Neodecanoic acid, is a chemical compound commonly used as an intermediate in the manufacturing of pharmaceuticals, dyes, and other organic compounds. It is a white to off-white crystalline powder that is soluble in water, alcohol, and other organic solvents. This chemical is often used as a pharmaceutical intermediate in the synthesis of various drugs, including antihistamines and local anesthetics. It is also used in the production of dyes, polymers, and rubber chemicals. Additionally, it can be employed as a corrosion inhibitor in metalworking fluids and as a surfactant in cleaning products.

InChI:InChI=1S/C5H13N.ClH/c1-5(2,3)4-6;/h4,6H2,1-3H3;1H

Upstream product

• 637-91-2 2,2-dimethylpropionaldehyde oxime 
• 102095-56-7 C₁₄H₃₀NO₅P 
• 5813-64-9 2.2-dimethylpropylamine 
• 75-84-3 2,2-dimethyl-propanol-1 
• 24590-75-8 2,2-Dimethyl-N-(1-methylethyliden)propylamin 
• 754-10-9 2,2-dimethylpropionamide 
• 630-18-2 tert-butyl isocyanide 

Downstream Products

• 15592-29-7 2,2-dimethylpropyl isocyanate 
• 1583283-65-1 C₂₁H₃₆N₃O₅P 
• 1583283-19-5 (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-neopentylpentanamide lithium 

Relevant articles and documents

Base-Catalyzed Hydrosilylation of Nitriles to Amines and Esters to Alcohols

Base-catalyzed hydrosilylation of nitriles to amines and esters to silylated alcohols is reported. This protocol tolerates electron-rich and electron-neutral olefins and works in the presence of basic functional groups (e. g. tertiary amines) but fails for acidic substrates, such as phenols and NH anilines. This catalytic system does not tolerate carbonyl groups, such as aldehydes, ketones, esters and carbamides, which are reduced to corresponding alcohols and amines. With the exact amount of silane, esters can be selectively reduced in the presence of nitriles, but the selectivity drops for the pairs ester/carboxamide and carboxamide/nitrile. Through competition experiments, the following preference in functional group reactivity was determined: ester > carboxamide > nitrile.

Catalytic Reduction of Nitriles by Polymethylhydrosiloxane Using a Phenalenyl-Based Iron(III) Complex

The reduction of nitriles to primary amines using an inexpensive silane such as polymethylhydrosiloxane (PMHS) is an industrially important reaction. Herein we report the synthesis of an earth-abundant Fe(III) complex bearing a phenalenyl-based ligand that was characterized by mass spectroscopy, elemental analysis, cyclic voltammetry, and single-crystal X-ray diffraction. The complex showed excellent catalytic activity toward reduction of aromatic, heteroaromatic, aliphatic, and sterically crowded nitriles to produce primary amines using polymethylhydrosiloxane (PMHS).

Ru-Catalyzed Transfer Hydrogenation of Nitriles, Aromatics, Olefins, Alkynes and Esters

This paper reports the preparation of new ruthenium(II) complexes supported by a pyrazole-phosphine ligand and their application to transfer hydrogenation of various substrates. These Ru complexes were found to be efficient catalysts for the reduction of nitriles and olefins. Heterocyclic compounds undergo transfer hydrogenation with good to moderate yields, affording examples of unusual hydrogenation of all-carbon-rings. Internal alkynes with bulky substituents show selective reduction to olefins with the unusual E–selectivity. Esters with strong electron-withdrawing groups can be reduced to the corresponding alcohols, if ethanol is used as the solvent. Possible mechanisms of hydrogenation and olefin isomerization are suggested on the basis of kinetic studies and labelling experiments.