159305-15-4

Basic information

• Product Name: Ethanone, 1-(2-amino-4-fluorophenyl)- (9CI)
• Synonyms: Ethanone, 1-(2-amino-4-fluorophenyl)- (9CI);1-(2-AMino-4-fluoro-phenyl)-ethanone
• CAS NO: 159305-15-4
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.1536232
• Product Categories: HALIDE;ACETYLGROUP
• Mol File: 159305-15-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 269.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.201±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.29±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-(2-amino-4-fluorophenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-amino-4-fluorophenyl)- (9CI)(159305-15-4)
• EPA Substance Registry System: Ethanone, 1-(2-amino-4-fluorophenyl)- (9CI)(159305-15-4)

Safety Data

• Hazardous Substances Data: 159305-15-4(Hazardous Substances Data)

Upstream product

• 372-19-0 meta-fluoroaniline 
• 446-08-2 2-amino-5-fluorobenzoic acid 
• 917-54-4 methyllithium 
• 394-01-4 4-fluoro-2-nitrobenzoic acid 
• 1214346-44-7 1-(4-fluoro-2-nitrophenyl)ethanone 
• 75-16-1 methylmagnesium bromide 
• 80517-22-2 2-amino-4-fluorobenzonitrile 
• 1438400-31-7 N-(2-acetyl-5-fluorophenyl)-4-methylbenzenesulfonamide 
• 446-32-2 4-fluoroanthranilic acid 

Downstream Products

• 159305-16-5 6-fluoro-3-methyl-1H-indazole 
• 391-83-3 7-fluoro-1,4-dihydroquinolin-4-one 
• 1363507-72-5 (S)-6-fluoro-3-methyl-2-benzofuran-1(3H)-one 
• 1363508-22-8 C₉H₈FNO 
• 1363508-10-4 2-acetyl-5-fluoro-benzonitrile 
• 1081504-62-2 C₂₈H₂₆FN₃O₅S 
• 1080674-67-4 C₂₉H₂₇FN₂O₆S 
• 1080674-69-6 C₂₆H₂₂FNO₆S 
• 1429782-02-4 C₁₀H₇Cl₃FNO₂ 
• 147197-81-7 7-fluoro-2-phenylquinolin-4(1H)-one 

Relevant articles and documents

Br?nsted acid/rhodium(II) cooperative catalytic asymmetric three-component aldol-type reaction for the synthesis of 3-amino oxindoles

Cooperation is key! Chiral Br?nsted acid/rhodium(II) cooperative catalysis enabled an enantioselective three-component aldol-type reaction of 3-diazo oxindoles and anilines with glyoxylates to give highly functionalized and structurally diverse 3-amino oxindoles in high stereoselectivity (>20:1 d.r., 99 % ee; see scheme). Copyright

QUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITORS

This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The pr

Highly stereoselective chemoenzymatic synthesis of the 3 h -isobenzofuran skeleton. access to enantiopure 3-methylphthalides

A straightforward synthesis of (S)-3-methylphthalides has been developed, with the key asymmetric step being the bioreduction of 2-acetylbenzonitriles. Enzymatic processes have been found to be highly dependent on the pH value, with acidic conditions being required to avoid undesired side reactions. Baker's yeast was found to be the best biocatalyst acting in a highly stereoselective fashion. The simple treatment of the reaction crudes with aqueous HCl has provided access to enantiopure (S)-3-methylphthalides in moderate to excellent yields.