391-83-3

Basic information

• Product Name: 7-FLUORO-4-HYDROXYQUINOLINE
• Synonyms: 4-Hydroxy-7-fluoroquinoline;7-Fluoro--Hydroxyquinoline;BUTTPARK 13\01-66;7-FLUOROQUINOLINE-4-OL;7-FLUORO-4-HYDROXYQUINOLINE;7-FLUORO-4-QUINOLINOL
• CAS NO: 391-83-3
• Molecular Formula: C₉H₆FNO
• Molecular Weight: 163.15
• Mol File: 391-83-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 262.4 °C at 760 mmHg
• Flash Point: 112.5 °C
• Appearance: /
• Density: 1.291 g/cm³
• Vapor Pressure: 0.0109mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 7-FLUORO-4-HYDROXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-FLUORO-4-HYDROXYQUINOLINE(391-83-3)
• EPA Substance Registry System: 7-FLUORO-4-HYDROXYQUINOLINE(391-83-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 391-83-3(Hazardous Substances Data)

Usage

General Description

7-Fluoro-4-hydroxyquinoline is a chemical compound with the molecular formula C9H6FNO. It is a derivative of quinoline, a heterocyclic aromatic compound, and is characterized by the presence of a fluorine atom at the 7th position and a hydroxyl group at the 4th position on the quinoline ring. 7-FLUORO-4-HYDROXYQUINOLINE has been extensively studied for its antimicrobial properties, and has been found to exhibit potent antibacterial and antifungal activity. It has been used in various pharmaceutical formulations and research studies aimed at developing new antibacterial agents. Additionally, 7-fluoro-4-hydroxyquinoline is also used as an intermediate in the synthesis of other organic compounds.

InChI:InChI=1/C9H6FNO/c10-6-1-2-7-8(5-6)11-4-3-9(7)12/h1-5H,(H,11,12)

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 138716-20-8 (E)-3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one 
• 25063-54-1 5-(((3-fluorophenyl)amino)methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 159305-15-4 1-(2-Amino-4-fluorophenyl)ethanone 
• 109-94-4 formic acid ethyl ester 
• 26892-97-7 7-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid ethyl ester 
• 26832-95-1 diethyl 2-(((3-fluorophenyl)amino)methylene)malonate 
• 372-19-0 meta-fluoroaniline 
• 183057-56-9 7-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 26892-97-7 ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate 
• 63463-20-7 7-Fluoro-4-hydroxyquinoline-3-carboxylic acid 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 5448-52-2 7-chloro-4-ethoxyquinoline 
• 26707-52-8 7-chloro-4-methoxyquinoline 
• 86-98-6 4,7-dichloroquinoline 
• 391-82-2 4-Chloro-7-fluoroquinoline 
• 256923-33-8 7-fluoro-3-nitro-4-quinolinol 
• 442-96-6 rac-N¹,N¹-diethyl-N⁴-(7-fluoroquinolin-4-yl)pentane-1,4-diamine 

Relevant articles and documents

3,6-DISUBSTITUTED-2-PYRIDINALDOXIME SCAFFOLDS

The present invention relates to a compound of formula (I), or one of its pharmaceutically acceptable salts: wherein R1, R2 and -X-Y- have specific definitions. It also relates to the use of such a compound as reactivator of acetylcholinesterase for treating organophosphorous nerve agents poisoning; and to a process for preparing it.

Design, synthesis and biological evaluation of new quinoline derivatives as potential antitumor agents

A series of new quinoline derivatives was designed, synthesized and evaluated for their antiproliferative activity. The results demonstrated that compounds 11p, 11s, 11v, 11x and 11y exhibited potent antiproliferative activity with IC50 value of lower than 10 μM against seven human tumor cell lines, and N-(3-methoxyphenyl)-7- (3-phenylpropoxy)quinolin-4-amine 11x was found to be the most potent antiproliferative agent against HCT-116, RKO, A2780 and Hela cell lines with an IC50 value of 2.56, 3.67, 3.46 and 2.71 μM, respectively. The antitumor efficacy of the representative compound 11x in mice was also evaluated, and the results showed that compound 11x effectively inhibited tumor growth and decreased tumor weight in animal models. Further investigation on mechanism of action indicated that compound 11x could inhibit colorectal cancer growth through ATG5-depenent autophagy pathway. Therefore, these quinoline derivatives are a new class of molecules that have the potential to be developed as new antitumor drugs.

With anti-tumor activity of chlorine oxygen kui derivatives

The invention relates to a chloroxoquinoline derivatives with anti-tumor activity and specifically relates to compounds of a formula I as shown in the specification and pharmaceutically acceptable salts, solvates and prodrugs thereof, wherein R1 is selected from hydrogen, -C1-6 alkyl, -C2-6 alkenyl, -C2-6 alkynyl and -C1-6 alkyl-phenyl, and the alkyl, the alkenyl, the alkynyl and the phenyl can be optionally substituted by halogens, nitryl, cyan, hydroxyl, -C1-6 alkoxy and phenyl; R3 is selected from hydrogen, -CONHR31 and -COOR32, the R31 and the R32 are independently selected from -C1-6 alkyl and -C1-6 alkylamino, respectively, and the amino can be optionally substituted by 1 to 2 -C1-6 alkyls; R7 is selected from halogens, -C1-6 alkoxy, morpholinyl and piperazine; the formula I is as shown in the specification.