15944-34-0

Basic information

• Product Name: 7-Chloro-[1,8]naphthyridin-2-ol
• Synonyms: 7-Chloro-1H-[1,8]naphthyridin-2-one;7-Chloro-[1,8]naphthyridin-2-ol
• CAS NO: 15944-34-0
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.5911
• Mol File: 15944-34-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 255-257℃
• Boiling Point: 404.688 °C at 760 mmHg
• Flash Point: 198.548 °C
• Appearance: /
• Density: 1.50
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.74±0.40(Predicted)
• CAS DataBase Reference: 7-Chloro-[1,8]naphthyridin-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-[1,8]naphthyridin-2-ol(15944-34-0)
• EPA Substance Registry System: 7-Chloro-[1,8]naphthyridin-2-ol(15944-34-0)

Safety Data

• Hazardous Substances Data: 15944-34-0(Hazardous Substances Data)

Usage

General Description

7-Chloro-[1,8]naphthyridin-2-ol is a chemical compound with the molecular formula C10H6ClNO. It is a chlorinated naphthyridine derivative with a hydroxyl group attached to the second carbon of the naphthyridine ring. 7-Chloro-[1,8]naphthyridin-2-ol is used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical drugs. It has also been studied for its potential biological activities, including as an antitumor and anti-inflammatory agent. Additionally, it has been identified as a potential scaffold for the development of new therapeutic agents. However, further research is needed to fully understand its pharmacological properties and potential applications.

InChI:InChI=1/C8H5ClN2O/c9-6-3-1-5-2-4-7(12)11-8(5)10-6/h1-4H,(H,10,11,12)

Upstream product

• 15944-33-9 2-chloro-7-amino-1,8-naphthyridine 
• 45644-21-1 6-chloropyridin-2-amine 
• 127446-34-8 N-(6-chloro-3-formylpyridin-2-yl)-2,2-dimethylpropionamide 
• 86847-84-9 2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide 
• 1931-44-8 2-amino-8H-7-oxo-[1,8]-naphthyridine 
• 127446-41-7 6-Chloro-2-<(2,2-dimethyl-1-oxopropyl)amino>-β-hydroxy-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester 
• 141-86-6 2.6-diaminopyridine 
• 1931-44-8 2-amino-7-hydroxy-1,8-naphthyridine 

Downstream Products

• 615568-69-9 methyl 7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridine-2-carboxylate 

Relevant articles and documents

Tailor-made naphthyridines: Self-assembling multiple hydrogen-bonded supramolecular architectures from dimer to helix

Stepwise changes of functional oxo and amino groups in 1,8-naphthyridines to modify the supramolecular architecture have been carried out. The first example of a naphthyridine helix has been found and its structure established by X-ray crystallography. The design is based on hydroxy and amido tautomeric naphthyridines which crystallize in dimers or catemers, one of them attaining helicity. The most stable tautomer present in all the compounds discussed in this paper, as well as the formation of hydrogen-bonded dimers or catemers, was established by X-ray crystallography and rationalized with theoretical calculations.

BICYCLIC ETHER O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS

Described herein are compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables Ar, X, R1, R3, R 4, Y1, Y2, n and p are as defined herein.

PIPERAZINE DERIVATIVE RENIN INHIBITORS

Disclosed are piperazine derivatives, their manufacture and use as inhibitors of renin. Formula (I):