15962-47-7Relevant articles and documents
PH-Dependent peptide bond formation by the selective coupling of α-amino acids in water
Wu, Long-Fei,Liu, Ziwei,Sutherland, John D.
supporting information, p. 73 - 76 (2021/01/13)
A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the amide bond. This journal is
Direct, facile synthesis of N-acyl-α-amino amides from α-keto esters and ammonia
Ntaganda, Rukundo,Milovic, Tamara,Tiburcio, Jorge,Thadani, Avinash N.
experimental part, p. 4052 - 4054 (2009/03/11)
N-Acyl-α-amino amides were prepared, without the necessity of chromatographic purification, in a single step by heating the corresponding α-keto ester in methanolic ammonia. The Royal Society of Chemistry.
Aqueous Solutions Containing Amino Acids and Peptides. Part 11.-Enthalpy of Dilution of Single and Binary Solute Solutions of N-Acetylglycine Amide, N-Acetyl-L-alanine Amide, N-Acetyl-L-valine Amide and N-Acetyl-L-leucine Amide at 298.15 K
Blackburn, G. Michael,Lilley, Terence H.,Walmsley, Elizabeth
, p. 915 - 922 (2007/10/02)
The enthalpies of dilution of aqueous solutions containing N-acetylglycine amide (G), N-acetyl-L-alanine amide (A), N-acetyl-L-valine amide (V) and N-acetyl-L-leucine amide (L) and equimolal solutions of G+A, G+V, G+L, A+V, A+L and V+L have been measured at 298.15 K.The results obtained have been used to calculate the pairwise enthalpy coefficients for like-like and like-unlike solute interactions.These coefficients have been compared with the predictions of the group additivity approach proposed earlier by Savage and Wood.The group additivity approach works well considering the experimental error and the standard deviation of the original correlations although it seems likely that some refinement of the group interaction parameters is required.
