1597-33-7

Basic information

• Product Name: 3-Amino-2-fluoropyridine
• Synonyms: 3-AMINO-2-FLUOROPYRIDINE;2-FLUORO-PYRIDIN-3-YLAMINE;2-Fluoro-3-aminopyridine;2-FLUOROPYRIDIN-3-AMINE;3-Amino-2-Fluoropyrine;3-AMINO-2-FLUOROPYIDINE;3-AMINE-2-FLUOROPYRIDIN;1597-33-7
• CAS NO: 1597-33-7
• Molecular Formula: C₅H₅FN₂
• Molecular Weight: 112.1050032
• EINECS: 145-896-5
• Product Categories: Pyridine;Pyridines
• Mol File: 1597-33-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 102°C/18mmHg(lit.)
• Flash Point: >110℃
• Appearance: /
• Density: 1.212
• Refractive Index: 1.563
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.18±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-2-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-2-fluoropyridine(1597-33-7)
• EPA Substance Registry System: 3-Amino-2-fluoropyridine(1597-33-7)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 20/21/22-36/37/38-36-22
• Safety Statements: 26-36-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1597-33-7(Hazardous Substances Data)

Usage

Description

3-Amino-2-fluoropyridine is an organic compound characterized by the presence of a fluorine atom and an amino group attached to a pyridine ring. It is a fluorinated building block and a valuable research chemical, widely utilized in the synthesis of various aromatic fluorinated compounds.

Uses

Used in Pharmaceutical Industry:
3-Amino-2-fluoropyridine is used as a key intermediate for the development of new pharmaceutical compounds. Its unique structure allows for the creation of novel drugs with potential applications in treating various diseases and medical conditions.
Used in Chemical Research:
3-Amino-2-fluoropyridine serves as a useful research chemical in the field of organic chemistry. It is employed in the preparation of other aromatic fluorinated compounds, contributing to the advancement of chemical research and the development of new materials and substances.
Used in Material Science:
In the field of material science, 3-Amino-2-fluoropyridine is used as a building block for the synthesis of advanced materials with specific properties. Its fluorinated nature and versatile chemical structure make it a valuable component in the development of new materials with potential applications in various industries, such as electronics, aerospace, and automotive.

InChI:InChI=1/BF4.Ca/c2-1(3,4)5;/q-1;+2

Upstream product

• 1480-87-1 2-fluoro-3-nitropyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 1089330-70-0 2-fluoropyridine-3-sulfonyl chloride 
• 1257881-52-9 (2-fluoro-pyridin-3-yl)-carbamic acid phenyl ester 
• 1285515-59-4 2-{[(2,4-difluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide 
• 1285515-56-1 2-{[(4-fluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide 
• 1285514-28-4 N-(2-fluoro-3-pyridinyl)-2-[(phenylmethyl)oxy]-5-(4-pyridinyl)benzamide 
• 850220-97-2 6-bromo-2-fluoropyridin-3-amine 
• 104149-51-1 dihydro-5,6 oxo-6 pyrido<2,3-e>pyrrolo<1,2-a>pyrazine 

Relevant articles and documents

The ortho effect in pyridines. Part XI(1). Substituent effects on basicity of 2- and 4-substituted 3-aminopyridines

The substituent effects on the pKa values corresponding to the first protonation site of thirty 2- and 4-substituted 3-aminopyridines have been studied.It was found that the relative localized and delocalized effects are apparently sensitive to the variation of substituent position in the pyridine ring.An interaction of the 2-substituent with the protonation centre has mainly inductive character, whereas, the pKa values of 4-substituted 3-aminopyridines are highly affected by through-resonance.The steric effect was found to be insignificant.Keywords: substituent effects / 2- and 4-substituted 3-aminopyridines / basicity