1600501-10-7Relevant articles and documents
Site-Selective Electrochemical C-H Cyanation of Indoles
Li, Laiqiang,Hou, Zhong-Wei,Li, Pinhua,Wang, Lei
, p. 5983 - 5987 (2021)
An electrochemical approach for the site-selective C-H cyanation of indoles employing readily available TMSCN as cyano source has been developed. The electrosynthesis relies on the tris(4-bromophenyl)amine as a redox catalyst, which achieves better yield and regioselectivity. A variety of C2- and C3-cyanated indoles were obtained in satisfactory yields. The reactions are conducted in a simple undivided cell at room temperature and obviate the need for transition-metal reagent and chemical oxidant.