16012-55-8 Usage
Description
L-BMAA HYDROCHLORIDE, also known as β-N-methylamino-l-alanine (BMAA), is a cyanobacterial neurotoxin derived from certain species of cyanobacteria. It has been a subject of interest due to its potential role in neurodegenerative diseases and its presence in various environmental sources.
Uses
Used in Environmental Analysis:
L-BMAA HYDROCHLORIDE is used as a standard for the analysis of BMAA isomers in desert crust material. This application helps researchers understand the distribution and concentration of BMAA in the environment, which can have implications for human and animal health.
Used in Biological Research:
L-BMAA HYDROCHLORIDE is used as an additive in the f/2+Si medium to treat the cells of Phaeodactylum tricornutum and Thalassiosira weissflogii. This application allows scientists to study the effects of BMAA on these marine microalgae, which can provide insights into the toxin's impact on marine ecosystems and the organisms that inhabit them.
Biochem/physiol Actions
L-BMAA hydrochloride helps to block the addition of heparan sulfate to glypican-1. It possesses unusual glutamate receptor binding properties. It may cause amyotrophic lateral sclerosis/Lou Gehrig′s disease.
Check Digit Verification of cas no
The CAS Registry Mumber 16012-55-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,0,1 and 2 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 16012-55:
(7*1)+(6*6)+(5*0)+(4*1)+(3*2)+(2*5)+(1*5)=68
68 % 10 = 8
So 16012-55-8 is a valid CAS Registry Number.
16012-55-8Relevant articles and documents
A simple and efficient approach to the synthesis of β-N-methylamino-l- alanine (BMAA)
Arévalo-García, Enzo B.,Colmenares Q., Juan Carlos
, p. 2335 - 2336 (2014/05/06)
A novel, efficient, and straightforward synthesis of β-N-methylamino- l-alanine (BMAA) in two steps starting from l-N,N-dibenzylserine benzyl ester is described. This method, in the light of other syntheses of BMAA, provides benefits such as mild reaction conditions, a simple work-up procedure, good yields, and the retention of the serine stereochemistry.
