16018-82-9

Basic information

• Product Name: N-(4-FLUOROPHENYL)IMIDODICARBONIMIDIC DIAMIDE HYDROCHLORIDE
• Synonyms: N-(4-fluorophenyl)imidodicarbonimidic diamide
• CAS NO: 16018-82-9
• Molecular Formula: C₈H₁₀FN₅
• Molecular Weight: 195.2
• Mol File: 16018-82-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 396.3°Cat760mmHg
• Flash Point: 193.5°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 1.72E-06mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: N-(4-FLUOROPHENYL)IMIDODICARBONIMIDIC DIAMIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-FLUOROPHENYL)IMIDODICARBONIMIDIC DIAMIDE HYDROCHLORIDE(16018-82-9)
• EPA Substance Registry System: N-(4-FLUOROPHENYL)IMIDODICARBONIMIDIC DIAMIDE HYDROCHLORIDE(16018-82-9)

Safety Data

• Hazardous Substances Data: 16018-82-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H10FN5/c9-5-1-3-6(4-2-5)13-8(12)14-7(10)11/h1-4H,(H6,10,11,12,13,14)

Upstream product

• 127099-85-8 N-Cyanoguanidine 
• 371-40-4 4-fluoroaniline 
• 16018-83-0 1-carbamimidamido-N-(4-fluorophenyl)methanimidamide hydrochloride 

Relevant articles and documents

NOVEL CYCLIC GMP-AMP SYNTHASE (CGAS) INHIBITORS AND THEIR METHOD OF USE

Methods of treating diseases related to cGAS activation. Small molecule inhibitors of cGAS and pharmaceutical compositions and uses thereof in treating autoimmune diseases or inflammation.

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, CONTAINING BIGUANIDE DERIVATIVE COMPOUND AS ACTIVE INGREDIENT

The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-α, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.