1602485-94-8

Basic information

• Product Name: (2R,3S)-1-chloro-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol
• Synonyms: (2R,3S)-1-chloro-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol
• CAS NO: 1602485-94-8
• Molecular Weight: 351.155
• Mol File: 1602485-94-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S)-1-chloro-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-1-chloro-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol(1602485-94-8)
• EPA Substance Registry System: (2R,3S)-1-chloro-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol(1602485-94-8)

Safety Data

• Hazardous Substances Data: 1602485-94-8(Hazardous Substances Data)

Upstream product

• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 1403893-61-7 4-chloro-5-fluoro-6-vinylpyrimidine 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF VORICONAZOLE AND ANALOGUES THEREOF

The present invention provides a process for preparing a compound of formula: (Formula XI and XII) (XI) (XII) wherein X, Y, Z, A, B and E are as defined herein, by reacting a compound of formula: (Formula XIII) (XIII) with a compound of formula: (Formula XIV and XV) (XIV) (XV) respectively, in the presence of a transition metal catalyst, a ligand suitable for use with 15 the catalyst and a reducing agent. The invention also provides novel intermediates.