1603-60-7Relevant articles and documents
ALKYLATION OF BENZENE WITH 4-METHYLCYCLOHEXANOL IN THE PRESENCE OF SULFURIC ACID
Lipovich, V. G.,Zemskov, V. V.,Ratovskii, G. V.,Burlakova, O. V.
, p. 109 - 112 (1990)
Alkylation of benzene with 4-methylcyclohexanol in the presence of methylcyclohexane and 96, 88, and 80percent H2SO4 has been studied.It was established that depending on the solubility of the starting components in sulfuric acid, alkylation occurs in the inorganic phase or on the interface between the organic and inorganic phases.The yield and composition of the catalysate are determined to a significant degree by the extent of the alkylation process and intramolecular hydride transfers.
Cobalt-Catalyzed Desymmetric Isomerization of Exocyclic Olefins
Lan, Yu,Liu, Qiang,Liu, Shihan,Liu, Xufang,Rong, Xianle
supporting information, p. 20633 - 20639 (2021/12/17)
Chiral cyclic olefins, 1-methylcyclohexenes, are versatile building blocks for the synthesis of pharmaceuticals and natural products. Despite the prevalence of these structural motifs, the development of efficient synthetic methods remains an unmet challenge. Herein we report a novel desymmetric isomerization of exocyclic olefins using a series of newly designed chiral cobalt catalysts, which enables a straightforward construction of chiral 1-methylcyclohexenes with diversified functionalities. The synthetic utility of this methodology is highlighted by a concise and enantioselective synthesis of a natural product, β-bisabolene. The versatility of the reaction products is further demonstrated by multifarious derivatizations.
REACTION OF 1-CHLORO-1-METHYLCYCLOHEXANE WITH PHENYL- AND BENZYL- TRIMETHYLSILANES IN THE PRESENCE OF ALUMINIUM CHLORIDE
Bolestova, G. I.,Parnes, Z. N.,Vol'pin, M. E.
, p. 967 - 971 (2007/10/02)
In the reaction of 1-chloro-1-methylcyclohexane with phenyltrimethylsilane and benzyltrimethylsilane in the presence of aluminum chloride the chlorine atom is substituted by a phenyl or benzyl group with the formation of 1-methyl-1-phenyl- and 1-methyl-1-benzylcyclohexane, respectively.In the case of benzyltrimethylsilane the products from alkylation of the benzene ring of the benzyltrimethylsilane by the 1-methylcyclohexyl carbocation in the Friedel-Crafts reaction are formed in addition to 1-methyl-1-benzylcyclohexane.