160332-70-7 Usage
Explanation
The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 8 carbon (C) atoms, 9 hydrogen (H) atoms, 1 bromine (Br) atom, and 2 oxygen (O) atoms.
Explanation
This is an alternative name for the compound, which is derived from its structure and the presence of bromine atoms.
Explanation
A chiral compound is one that has a chiral center, which means it cannot be superimposed on its mirror image. This compound has a chiral center at the carbon atom bonded to the hydroxyl group and the phenyl group.
Explanation
Enantiomers are non-superimposable mirror images of each other. The compound exists in two enantiomeric forms, (1R) and (1S), which are distinguished by the absolute configuration at the chiral center.
Explanation
The (1S)-enantiomer of the compound has specific optical rotation properties, which means it can rotate the plane of polarized light in a specific direction.
Explanation
The compound is used as an intermediate in organic synthesis and is also utilized in the production of pharmaceuticals and agrochemicals. It has potential applications in the fields of medicine and biotechnology.
Explanation
The compound can be used as a building block in the synthesis of various complex organic molecules, which can be further modified or functionalized for specific applications.
Explanation
The compound is likely to be soluble in organic solvents such as ethanol, methanol, and acetone due to its polar nature and the presence of a hydroxyl group.
Explanation
The compound is generally stable under normal conditions, such as room temperature and pressure, and does not readily decompose or react with other substances.
Explanation
As with many chemicals, 1,2-Ethanediol, 1-(4-bromophenyl)-, (1S)may pose health risks if not handled properly. It can be an irritant and is toxic if ingested, inhaled, or absorbed through the skin. Proper safety measures should be taken when working with this compound.
Chiral Compound
Yes
Enantiomeric Forms
(1R) and (1S) enantiomers
Specific Optical Rotation
(1S)-enantiomer
Applications
Organic synthesis, pharmaceuticals, agrochemicals, medicine, biotechnology
Building Block
Synthesis of complex organic molecules
Solubility
Soluble in organic solvents
Stability
Stable under normal conditions
Hazardous Properties
Potential irritant, toxic by ingestion, inhalation, or skin absorption
Check Digit Verification of cas no
The CAS Registry Mumber 160332-70-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,0,3,3 and 2 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 160332-70:
(8*1)+(7*6)+(6*0)+(5*3)+(4*3)+(3*2)+(2*7)+(1*0)=97
97 % 10 = 7
So 160332-70-7 is a valid CAS Registry Number.
160332-70-7Relevant articles and documents
Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors
Hoff, Katharina,Mielniczuk, Sebastian,Agoglitta, Oriana,Iorio, Maria Teresa,Caldara, Manlio,Bülbül, Emre F.,Melesina, Jelena,Sippl, Wolfgang,Holl, Ralph
, (2020)
The bacterial deacetylase LpxC is a promising target for the development of antibiotics selectively combating Gram-negative bacteria. To improve the biological activity of the reported benzyloxyacetohydroxamic acid 9 ((S)-N-hydroxy-2-{2-hydroxy-1-[4-(phenylethynyl)phenyl]ethoxy}acetamide), its hydroxy group was replaced by a triazole ring. Therefore, in divergent syntheses, triazole derivatives exhibiting rigid and flexible lipophilic side chains, different configurations at their stereocenter, and various substitution patterns at the triazole ring were synthesized, tested for antibacterial and LpxC inhibitory activity, and structure-activity relationships were deduced based on docking and binding energy calculations.
Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of (: R)-1,2-diols from racemic epoxides
Hu, Die,Zong, Xun-Cheng,Xue, Feng,Li, Chuang,Hu, Bo-Chun,Wu, Min-Chen
supporting information, p. 2799 - 2802 (2020/03/13)
Both the activity and regioselectivity of Phaseolus vulgaris epoxide hydrolase were remarkably improved via reshaping two substrate tunnels based on rational design. The elegant one-step enantioconvergent hydrolysis of seven rac-epoxides was achieved by single mutants, allowing green and efficient access to valuable (R)-1,2 diols with high eep (90.1-98.3%) and yields.
Chiral Ion-Pair Organocatalyst-Promoted Efficient Enantio-selective Reduction of α-Hydroxy Ketones
Zhang, Yiliang,He, Li,Shi, Lei
, p. 1926 - 1931 (2018/03/27)
The enantioselective reduction of α-hydroxy ketones with catecholborane has been developed employing 5 mol% of an 1,1′-bi-2-naphthol (BINOL)-derived ion-pair organocatalyst. This methodology provides a straightforward access to the corresponding aromatic 1,2-diols in high yields (up to 90%) with excellent enantioselectivities (up to 97%). Furthermore, the α-amino ketones also could be reduced with moderate ee values under mild reaction condition. (Figure presented.).
