16071-26-4

Basic information

• Product Name: (R)-2-chloro-diphenylmethanol
• Synonyms: (R)-2-chloro-diphenylmethanol;(alphaR)-2-Chloro-alpha-phenylbenzenemethanol
• CAS NO: 16071-26-4
• Molecular Formula: C₁₃H₁₁ClO
• Molecular Weight: 218.6788
• Mol File: 16071-26-4.mol
• Article Data: 54

Chemical Properties

• Boiling Point: 344.1 °C at 760 mmHg
• Flash Point: 161.9 °C
• Appearance: /
• Density: 1.221
• Vapor Pressure: 2.57E-05mmHg at 25°C
• Refractive Index: 1.609
• PKA: 13.17±0.20(Predicted)
• CAS DataBase Reference: (R)-2-chloro-diphenylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-chloro-diphenylmethanol(16071-26-4)
• EPA Substance Registry System: (R)-2-chloro-diphenylmethanol(16071-26-4)

Safety Data

• Hazardous Substances Data: 16071-26-4(Hazardous Substances Data)

Usage

General Description

(R)-2-chloro-diphenylmethanol, also known as R-CDPM, is a chemical compound with the molecular formula C13H11ClO. It is a chiral compound, meaning that it has a non-superimposable mirror image. R-CDPM is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been investigated for its potential use as a chiral auxiliary in organic synthesis. Additionally, R-CDPM has been studied for its antimicrobial and antioxidant properties, making it potentially useful in the development of new drugs and functional materials. Overall, R-CDPM is a versatile chemical with various potential applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C13H11ClO/c14-12-9-5-4-8-11(12)13(15)10-6-2-1-3-7-10/h1-9,13,15H/t13-/m1/s1

Upstream product

• 5162-03-8 (2-chlorophenyl)(phenyl)methanone 
• 89-98-5 2-chloro-benzaldehyde 
• 95950-06-4 1,2-bis-(2-chloro-phenyl)-1,2-diphenyl-ethane-1,2-diol 
• 108-38-3 m-xylene 
• 109-72-8 n-butyllithium 
• 17051-75-1 o-chlorophenyl phenyl sulfoxide 
• 100-52-7 benzaldehyde 
• 15842-76-9 (2-chloro-phenyl)-trimethyl-silane 
• 76847-21-7 2-Chlor-1-benzol 
• 64-17-5 ethanol 
• 694-80-4 2-bromo-1-chlorobenzene 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 591-51-5 phenyllithium 
• 611-17-6 1-bromomethyl-2-chlorobenzene 

Downstream Products

• 29921-41-3 (o-benzyl)chlorobenzene 
• 56961-47-8 2-chloro-benzhydryl chloride 
• 7732-18-5 water 
• 16071-25-3 (S)-2-chlorobenzhydrol 

Relevant articles and documents

Bio-inspired asymmetric aldehyde arylations catalyzed by rhodium-cyclodextrin self-inclusion complexes

Transition-metal catalysts are powerful tools for carbon-carbon bond-forming reactions that are difficult to achieve using native enzymes. Enzymes that exhibit inherent selectivities and reactivities through host-guest interactions have inspired widesprea

4-Methyltetrahydropyran (4-MeTHP): Application as an Organic Reaction Solvent

4-Methyltetrahydropyran (4-MeTHP) is a hydrophobic cyclic ether with potential for industrial applications. We herein report, for the first time, a comprehensive study on the performance of 4-MeTHP as an organic reaction solvent. Its broad application to organic reactions includes radical, Grignard, Wittig, organometallic, halogen-metal exchange, reduction, oxidation, epoxidation, amidation, esterification, metathesis, and other miscellaneous organic reactions. This breadth suggests 4-MeTHP can serve as a substitute for conventional ethers and harmful halogenated solvents. However, 4-MeTHP was found incompatible with strong Lewis acids, and the C?O bond was readily cleaved by treatment with BBr3. Moreover, the radical-based degradation pathways of 4-MeTHP, THP and 2-MeTHF were elucidated on the basis of GC-MS analyses. The data reported herein is anticipated to be useful for a broad range of synthetic chemists, especially industrial process chemists, when selecting the reaction solvent with green chemistry perspectives.

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase

Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of inflammatory and immunosuppressive activities. Whereas inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) have been reported and analyzed in the clinic, fewer inhibitors have been described for tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase-2 (IDO2) which also have been implicated more recently in cancer, inflammation and immune control. Consequently the development of dual or pan inhibitors of these Trp catabolizing enzymes may represent a therapeutically important area of research. This is the first report to describe the development of dual and pan inhibitors of IDO1, TDO and IDO2.