16089-71-7

Basic information

• Product Name: N-methyl-N-(4-nitrobenzylidene)amine oxide
• CAS NO: 16089-71-7
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.1607
• Mol File: 16089-71-7.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 348.5°C at 760 mmHg
• Flash Point: 178.3°C
• Density: 1.275g/cm³
• Vapor Pressure: 0.000101mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: N-methyl-N-(4-nitrobenzylidene)amine oxide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(4-nitrobenzylidene)amine oxide(16089-71-7)
• EPA Substance Registry System: N-methyl-N-(4-nitrobenzylidene)amine oxide(16089-71-7)

Safety Data

• Hazardous Substances Data: 16089-71-7(Hazardous Substances Data)

Upstream product

• 1129-37-9 4-nitrobenzaldoxime 
• 77-78-1 dimethyl sulfate 
• 1129-37-9 4-nitrobenzaldehyde oxime 
• 186581-53-3 diazomethane 
• 28958-67-0 trans-2-methyl-3-(p-nitrophenyl)oxaziridine 
• 28944-73-2 cis-2-methyl-3-(p-nitrophenyl)oxaziridine 
• 191991-28-3 N-p-nitrobenzyl-N-methylhydroxylamine 
• 4229-44-1 N-methylhydroxyamine hydrochloride 
• 555-16-8 4-nitrobenzaldehdye 
• 57777-70-5 α,α-adamantylidene-N-methyl nitrone 
• 593-77-1 N-Methylhydroxylamine 
• 19499-60-6 N-methyl-4-nitrobenzylamine 
• 3400-11-1 N-methylhydroxylamine-O-sulphonic acid 
• 25105-58-2 N-(p-nitrobenzylidene)ethylamine 

Downstream Products

• 16089-71-7 N-(p-nitrobenzylidene)methylamine N-oxide 
• 555-16-8 4-nitrobenzaldehdye 
• 593-77-1 N-Methylhydroxylamine 
• 74-89-5 methylamine 
• 267238-11-9 trans-[PtCl₄(N=C(Me)O-N(Me)-C(H)(p-C₆H₄NO₂))2] 
• 1245730-40-8 (3S,5S)-5-methyl-3-(4-nitrophenyl)-2-methylisoxazolidine-5-carbaldehyde 

Relevant articles and documents

A facile and new method for the synthesis of α-aryl-N-methylnitrones in solvent-free media using silica gel-NaOH

Substituted α-aryl-N-methylnitrones are prepared by the condensation reaction of N-methylhydroxylamine hydrochloride and benzaldehydes in solvent-free media using silica-gel-NaOH catalyst system. The yields are excellent regardless of the electron-donatin

A green synthesis of nitrones in glycerol

Abstract: An eco-friendly and efficient synthesis of nitrones is presented by condensation of an equimolar amount of aldehydes and N-substituted hydroxylamine hydrochlorides in glycerol as a recyclable solvent-catalyst. This novel protocol provides rapid and mild access to a series of nitrone derivatives in good to excellent yields in the absence of catalyst and base. Graphic abstract: SYNOPSIS In this study, a base-free protocol by using glycerol as the solvent-catalyst was applied for an eco-friendly synthesis of nitrones from the condensation of aldehydes and N-substituted hydroxylaminehydrochlorides.[Figure not available: see fulltext.].

BPh3-Catalyzed [2+3] Cycloaddition of Ph3PCCO with Aldonitrones: Access to 5-Isoxazolidinones with Exocyclic Phosphonium Ylide Moieties

A method for the generation of 5-isoxazolidinones with exocyclic phosphonium ylide functionalities via [2+3] cycloaddition of Ph3PCCO and aldonitrones has been developed and applied in the synthesis of 4-alkylidene-5-isoxazolidinones via Wittig olefination. The reaction proceeds by BPh3 catalysis under mild conditions and with a broad substrate scope. A reaction pathway involving the activation of the aldonitrone via interactions with the Lewis acid BPh3 is proposed.