1609102-43-3

Basic information

• Product Name: 8-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-7-ene
• Synonyms: 8-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-7-ene
• CAS NO: 1609102-43-3
• Molecular Weight: 261.277
• Mol File: 1609102-43-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 8-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-7-ene(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-7-ene(1609102-43-3)
• EPA Substance Registry System: 8-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-7-ene(1609102-43-3)

Safety Data

• Hazardous Substances Data: 1609102-43-3(Hazardous Substances Data)

Upstream product

• 1190757-88-0 8-bromo-1, 4-dioxaspiro[4.5]dec-7-ene 
• 15163-59-4 potassium o-nitrobenzoate 
• 552-16-9 ortho-nitrobenzoic acid 
• 577-19-5 2-nitrophenyl bromide 
• 195436-65-8 4-methyl-N'-(1,4-dioxaspiro[4.5]decan-8-ylidene)benzenesulfonohydrazide 

Relevant articles and documents

A palladium-catalyzed Barluenga cross-coupling – Reductive cyclization sequence to substituted indoles

A short and flexible synthesis of substituted indoles employing two palladium-catalyzed reactions, a Barluenga cross-coupling of p-tosylhydrazones with 2-nitroarylhalides followed by a palladium–catalyzed, carbon monoxide–mediated reductive cyclization has been developed. A one-pot, two-step methodology was further developed, eliminating isolation and purification of the cross-coupling product. This was accomplished by utilizing the initially added 0.025 equivalents of bis(triphenylphosphine)palladium dichloride, thus serving a dual role in the cross-coupling and the reductive cyclization. It was found that addition of 1,3-bis(diphenylphosphino)propane and carbon monoxide after completion of the Barluenga reaction afforded, in most cases, significantly better overall yields.