1609395-32-5Relevant articles and documents
A Dinuclear Persulfide-Bridged Ruthenium Compound is a Hypoxia-Selective Hydrogen Sulfide (H2S) Donor
Woods, Joshua J.,Wilson, Justin J.
, p. 1588 - 1592 (2021)
Hydrogen sulfide (H2S) is a gaseous molecule that has received attention for its role in biological processes and therapeutic potential in diseases, such as ischemic reperfusion injury. Despite its clinical relevance, delivery of H2S to biological systems is hampered by its toxicity at high concentrations. Herein, we report the first metal-based H2S donor that delivers this gas selectively to hypoxic cells. We further show that H2S release from this compound protects H9c2 rat cardiomyoblasts from an in vitro model of ischemic reperfusion injury. These results validate the utility of redox-activated metal complexes as hypoxia-selective H2S-releasing agents for use as tools to study the role of this gaseous molecule in complex biological systems.
Rational design and bioimaging applications of highly selective fluorescence probes for hydrogen polysulfides
Liu, Chunrong,Chen, Wei,Shi, Wen,Peng, Bo,Zhao, Yu,Ma, Huimin,Xian, Ming
supporting information, p. 7257 - 7260 (2014/06/09)
Reactive sulfur species have received considerable attention due to their various biological functions. Among these molecules, hydrogen polysulfides (H2Sn, n > 1) are recently suggested to be the actual signaling molecules derived from hydrogen sulfide (H2S). Hydrogen polysulfides may also have their own biosynthetic pathways. The research on H2Sn is rapidly growing. However, the detection of H 2Sn is still challenging. In this work we report a H 2Sn-mediated benzodithiolone formation under mild conditions. Based on this reaction, specific fluorescent probes for H 2Sn are prepared and evaluated. The probe DSP-3 shows good selectivity and sensitivity for H2Sn.