1612179-01-7

Basic information

• Product Name: N-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}-5-methoxypyridine-3-carboxamide
• CAS NO: 1612179-01-7
• Molecular Weight: 374.87
• Mol File: 1612179-01-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}-5-methoxypyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}-5-methoxypyridine-3-carboxamide(1612179-01-7)
• EPA Substance Registry System: N-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}-5-methoxypyridine-3-carboxamide(1612179-01-7)

Safety Data

• Hazardous Substances Data: 1612179-01-7(Hazardous Substances Data)

Upstream product

• 27828-71-3 5-hydroxynicotinic acid 
• 40255-46-7 2-(4-(4-chlorophenyl)-piperazin-1-yl)-ethanamine 

Relevant articles and documents

Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors

We report the synthesis of compounds structurally related to the high-affinity dopamine D4 receptor ligand N-{2-[4-(3-cyanopyridin-2- yl)piperazin-1-yl]ethyl}-3-methoxybenzamide (1e). All compounds were specifically designed as potential PET radioligands for brain D4 receptor visualization, having lipophilicity within a range for brain uptake and weak non-specific binding (0.75a substituent for easy access to labeling with the positron emitter isotope 11C or 18F. The best compound of the series, N-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}-6- fluoropyridine-3-carboxamide (7a), displayed excellent selectivity over D 2 and D3 receptors (>100-fold), but its D4 receptor affinity was suboptimal for imaging of brain D4 receptors (Ki=30 nm).