16150-45-1 Usage
Description
Diethyl cromoglycate is a derivative of Sodium cromoglycate, a bischromone compound with anti-inflammatory properties. It is known for its ability to prevent the release of histamine in the body, making it a potential candidate for various pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
Diethyl cromoglycate is used as a prophylactic treatment for bronchial asthma. It functions by preventing the release of histamine, which is a key mediator in the inflammatory response associated with asthma. This helps in managing and maintaining the condition, providing relief from asthma symptoms.
Additionally, due to its anti-inflammatory properties, Diethyl cromoglycate may have potential applications in other areas of the pharmaceutical industry, such as treating allergies or other conditions involving histamine release. However, further research and development would be required to explore these possibilities.
Check Digit Verification of cas no
The CAS Registry Mumber 16150-45-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,1,5 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 16150-45:
(7*1)+(6*6)+(5*1)+(4*5)+(3*0)+(2*4)+(1*5)=81
81 % 10 = 1
So 16150-45-1 is a valid CAS Registry Number.
InChI:InChI=1/C27H24O11/c1-3-33-26(31)22-11-16(29)24-18(7-5-9-20(24)37-22)35-13-15(28)14-36-19-8-6-10-21-25(19)17(30)12-23(38-21)27(32)34-4-2/h5-12,15,28H,3-4,13-14H2,1-2H3
16150-45-1Relevant articles and documents
Preparation method of diethyl cromoglycate and sodium cromoglycate
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Paragraph 0085-0086; 0088-0089; 0091-0092, (2021/02/20)
The invention relates to the technical field of medicines, in particular to a preparation method of diethyl cromoglycate and sodium cromoglycate. The preparation method comprises the following steps:reacting 2, 6-dihydroxy acetophenone with diethyl oxalate to obtain 7-hydroxy-4-oxo-4H-benzopyran-2-carboxylic acid ethyl ester, and then reacting with 1, 3-dibromo-2-propanol(or epoxy chloropropane)to prepare diethyl cromoglycinate, because one phenolic hydroxyl group in the 7-hydroxy-4-oxo-4H-benzopyran-2-carboxylic acid ethyl ester molecule is protected, cutting off the source of polymolecularpolycondensation reaction, wherein two reaction sites of 1, 3-dibromo-2-propanol(or epoxy chloropropane) need to participate in the reaction, and obtaining the unique product diethyl cromoglycate through the reaction. Therefore, the yield of the diethyl cromoglycate is very high.
MACROPHAGES/MICROGLIA IN NEURO-INFLAMMATION ASSOCIATED WITH NEURODEGENERATIVE DISEASES
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Page/Page column 22, (2018/03/25)
Described herein are methods of treating neuron inflammation conditions, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, ischemic stroke, and prion disease, comprising administering a therapeutically effective amount of cromol
Pro-drugs for the oral delivery of disodium cromoglycate
Mori,Nishimura,Tamaki,Nakamura,Tsuda,Kakeya
, p. 338 - 344 (2007/10/02)
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